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This review evaluates preclinical evidence regarding the efficacy and safety of RSV as a therapeutic bone agent using different rat models. Limitations of these animal models are discussed, and suggestions for strengthening the experimental design of future studies are provided. The ovariectomized rat model of postmenopausal osteoporosis reported that RSV supplementation attenuated estrogen deficiency\u2013induced bone loss and trabecular structural deterioration. RSV safety was indicated by the absence of stimulation of estrogen\u2010sensitive tissue. Providing RSV to rats aged &gt;6 months attenuated age\u2010related bone mass loss and structural deterioration but produced inconsistent effects on bones in rats aged &lt;6 months. The hindlimb\u2010suspension rat model of disuse osteoporosis reported that RSV attenuated bone loss in old rats, but higher doses and longer duration supplementation before mechanical loading were required for younger rats. Limitations common to studies using rat models of osteoporosis include requirements to include animals that are skeletally mature, longer study durations, and to adjust for potential confounding effects due to altered body weight and endocrine function. Strengthening experimental design can contribute to translation of animal results to clinically relevant recommendations for humans.<\/jats:p>","DOI":"10.1111\/nyas.12840","type":"journal-article","created":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T13:18:59Z","timestamp":1437571139000},"page":"75-85","source":"Crossref","is-referenced-by-count":29,"title":["Evaluating resveratrol as a therapeutic bone agent: preclinical evidence from rat models of osteoporosis"],"prefix":"10.1111","volume":"1348","author":[{"given":"Janet C.","family":"Tou","sequence":"first","affiliation":[{"name":"Human Nutrition and Foods, Division of Animal and Nutritional Sciences West Virginia University Morgantown West Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2008.03.027"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1749-799X-6-30"},{"key":"e_1_2_8_4_1","first-page":"416","article-title":"Strong bones in later life: luxury or necessity","volume":"77","author":"Delmas P.D.","year":"1999","journal-title":"Bull. 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