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This process, epithelial barrier function, is basic for proper function of all organs, including the lung, liver, gastrointestinal tract, reproductive tract, blood\u2013brain barrier, and kidney. Specifically, MR has been found to modify the protein composition of tight junctional complexes surrounding individual epithelial cells in a manner that renders the complexes less leaky. This has been observed in both a renal epithelial cell culture model and in gastrointestinal tissue. In both cases, MR increased the transepithelial electrical resistance across the epithelium, while decreasing passive leak of small nonelectrolytes. However, the specific target protein modifications involved were unique to each case. Overall, this provides an example of the primary level on which MR functions to modify, and improve, an organism.<\/jats:p>","DOI":"10.1111\/nyas.12955","type":"journal-article","created":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T08:14:48Z","timestamp":1449648888000},"page":"59-67","source":"Crossref","is-referenced-by-count":10,"title":["Methionine restriction fundamentally supports health by tightening epithelial barriers"],"prefix":"10.1111","volume":"1363","author":[{"given":"James M.","family":"Mullin","sequence":"first","affiliation":[{"name":"Lankenau Institute for Medical Research Wynnewood Pennsylvania"},{"name":"Division of Gastroenterology Lankenau Medical Center Wynnewood Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja M.","family":"Skrovanek","sequence":"additional","affiliation":[{"name":"Lankenau Institute for Medical Research Wynnewood Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arivudainambi","family":"Ramalingam","sequence":"additional","affiliation":[{"name":"Lankenau Institute for Medical Research Wynnewood Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine M.","family":"DiGuilio","sequence":"additional","affiliation":[{"name":"Lankenau Institute for Medical Research Wynnewood Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary C.","family":"Valenzano","sequence":"additional","affiliation":[{"name":"Lankenau Institute for Medical Research Wynnewood Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(05)03379-9"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-003-0219-y"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb05235.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6107(02)00037-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2001.00970.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(03)00089-3"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.3.439"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2002.tb00430.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5424.103"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(03)00338-1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1640-04.2004"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)02004-X"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700050"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700251"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00187.2003"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v10.i17.2514"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2741\/3413"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02630"},{"key":"e_1_2_8_20_1","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.4049\/jimmunol.150.6.2356","article-title":"IFN\u2010gamma modulation of epithelial barrier function. 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