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Axial bone formation and the combination of concurrent erosion and new bone formation are specific characteristics of SpA disease. The use of antiproinflammatory cytokines, such as inhibitors of tumor necrosis factor \u03b1 (TNF\u2010\u03b1), appears to be the greatest advance in the treatment of SpA over the past 20 years. However, TNF\u2010\u03b1 blockers do not halt new bone formation. Recent clinical observations and animal studies demonstrate that Wnt signaling proteins and natural Wnt inhibitors, such as DKK1 and sclerostin, are likely to play important roles in the process of ankylosis in SpA, and could potentially serve as therapeutic targets for the treatment of SpA.<\/jats:p>","DOI":"10.1111\/nyas.12968","type":"journal-article","created":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T22:33:32Z","timestamp":1449095612000},"page":"25-31","source":"Crossref","is-referenced-by-count":51,"title":["Wnt\/\u03b2\u2010catenin signaling plays a key role in the development of spondyloarthritis"],"prefix":"10.1111","volume":"1364","author":[{"given":"Wanqing","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Biochemistry Rush University Medical Center  Chicago Illinois"},{"name":"Liaoning University of Traditional Chinese Medicine  Shenyang 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