{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T10:48:42Z","timestamp":1787136522615,"version":"build-2736575974"},"reference-count":145,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,8]],"date-time":"2016-01-08T00:00:00Z","timestamp":1452211200000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>Prostaglandins (PGs) are produced via cyclooxygenases, which are enzymes that play a major role in neuroinflammation. Epidemiological studies show that chronic treatment with low levels of cyclooxygenase inhibitors (nonsteroidal anti\u2010inflammatory drugs (NSAIDs)) lowers the risk for Alzheimer's disease (AD) and Parkinson's disease (PD) by as much as 50%. Unfortunately, inhibiting cyclooxygenases with NSAIDs blocks the synthesis of downstream neuroprotective and neurotoxic PGs, thus producing adverse side effects. We focus on prostaglandin J2 (PGJ2) because it is highly neurotoxic compared to PGA1, D2, and E2. Unlike other PGs, PGJ2 and its metabolites have a cyclopentenone ring with reactive \u03b1,\u03b2\u2010unsaturated carbonyl groups that form covalent Michael adducts with key cysteines in proteins and GSH. Cysteine\u2010binding electrophiles such as PGJ2 are considered to play an important role in determining whether neurons will live or die. We discuss <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> studies showing that PGJ2 induces pathological processes relevant to neurodegenerative disorders such as AD and PD. Further, we discuss our work showing that increasing intracellular cAMP with the lipophilic peptide PACAP27 counteracts some of the PGJ2\u2010induced detrimental effects. New therapeutic strategies that neutralize the effects of specific neurotoxic PGs downstream from cyclooxygenases could have a significant impact on the treatment of chronic neurodegenerative disorders with fewer adverse side effects.<\/jats:p>","DOI":"10.1111\/nyas.12987","type":"journal-article","created":{"date-parts":[[2016,1,10]],"date-time":"2016-01-10T17:28:05Z","timestamp":1452446885000},"page":"125-137","source":"Crossref","is-referenced-by-count":43,"title":["Prostaglandin J2: a potential target for halting inflammation\u2010induced neurodegeneration"],"prefix":"10.1111","volume":"1363","author":[{"given":"Maria E.","family":"Figueiredo\u2010Pereira","sequence":"first","affiliation":[{"name":"Department of Biological Sciences Hunter College and the Graduate Center, CUNY  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuhyon","family":"Corwin","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Hunter College and the Graduate Center, CUNY  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Babich","sequence":"additional","affiliation":[{"name":"Department of Radiology Weill Cornell Medical College  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,8]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(11)70065-7"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)70016-5"},{"key":"e_1_2_15_4_1","first-page":"a006346","article-title":"Inflammation in Alzheimer disease\u2014a brief review of the basic science and clinical literature","volume":"2","author":"Wyss\u2010Coray T.","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.207449"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI58656"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00028"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/628192"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3880"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.01.010"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03264.x"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-007-0058-8"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-015-0126-1"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.10.028"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211851"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211103"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3435"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.04.014"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-8-19"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e3280adc943"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000311269.57716.63"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31820f2d79"},{"key":"e_1_2_15_23_1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/9781118743614.ch14","volume-title":"Ibuprofen in Prevention of Neurodegenerative Diseases, Ibuprofen: Discovery, Development and Therapeutics","author":"Rainsford K.D.","year":"2015"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/1-4020-5688-5_1"},{"key":"e_1_2_15_25_1","first-page":"19","article-title":"Are NSAIDs useful to treat Alzheimer's disease or mild cognitive impairment","volume":"2","author":"Imbimbo B.P.","year":"2010","journal-title":"Front. Aging Neurosci"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2008.05.002"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.2174\/18715273113126660170"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2014.00104"},{"issue":"1","key":"e_1_2_15_29_1","first-page":"220","article-title":"The role of eicosanoids in the brain","volume":"17","author":"Tassoni D.","year":"2008","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800094-JLR200"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2011.11.006"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2007.12.016"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1358\/mf.2000.22.5.796648"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324143"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.56.3.3"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-6980(02)00061-8"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.294.5548.1871"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.2174\/157015910790909485"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2010.09.009"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2009.01.002"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90192-T"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2003.12.009"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.6361"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.02045.x"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI46279"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI77487"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2013.11.041"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1989.tb22600.x"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1984.tb06680.x"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02870.x"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00314401"},{"key":"e_1_2_15_52_1","first-page":"318","article-title":"Estradiol differentially regulates lipocalin\u2010type prostaglandin D synthase transcript levels in the rodent brain: evidence from high\u2010density oligonucleotide arrays and in situ hybridization","volume":"100","author":"Mong J.A.","year":"2003","journal-title":"Methods Mol. Biol."},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-6980(02)00042-4"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jnen.0000240472.43038.27"},{"key":"e_1_2_15_55_1","first-page":"6412","article-title":"Lipocalin\u2010type prostaglandin D synthase\/beta\u2010trace is a major amyloid beta\u2010chaperone in human cerebrospinal fluid","volume":"104","author":"Kanekiyo T.","year":"2007","journal-title":"Methods Mol. Biol."},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2004.09.008"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0083-6729(00)58022-4"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(07)82012-5"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1155\/2006\/241817"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2013.08.001"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2005.tb00512.x"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.09.020"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-013-9377-4"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.29"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2010.1723"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2009.06.005"},{"key":"e_1_2_15_67_1","first-page":"7367","article-title":"15\u2010Deoxy\u2010Delta(12,14)\u2010prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis","volume":"99","author":"Kondo M.","year":"2002","journal-title":"Methods Mol. Biol."},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.05.098"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M600635200"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M601201200"},{"key":"e_1_2_15_71_1","first-page":"6835","article-title":"Cyclopentenone prostaglandin\u2010induced unfolding and aggregation of the Parkinson disease\u2010associated UCH\u2010L1","volume":"107","author":"Koharudin L.M.","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh308"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M102198200"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2009.06.100"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005030329"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M009630200"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M400392-JLR200"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1139\/y05-147"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2004.06.003"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.7.3563"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2266"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2009.12.013"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046103"},{"key":"e_1_2_15_84_1","first-page":"283","article-title":"Peroxisome proliferator activated receptor\u2010gamma and traumatic brain injury","volume":"3","author":"Qi L.","year":"2010","journal-title":"Int. J. Clin. Exp. Med."},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.2741\/2802"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/418765"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20630"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.1006"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2006.11.004"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20111752"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/mas.21389"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0320151"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20091293"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201200289"},{"key":"e_1_2_15_95_1","doi-asserted-by":"crossref","first-page":"e17552","DOI":"10.1371\/journal.pone.0017552","article-title":"Proteomic identification of protein targets for 15\u2010deoxy\u2010Delta(12,14)\u2010prostaglandin J2 in neuronal plasma membrane","volume":"6","author":"Yamamoto Y.","journal-title":"PLoS ONE"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/mas.21383"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(01)02154-8"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00369"},{"key":"e_1_2_15_99_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-1-5"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.8.5196"},{"key":"e_1_2_15_101_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001813-200411000-00004"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.12.8328"},{"key":"e_1_2_15_103_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.12.7104"},{"key":"e_1_2_15_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.06.020"},{"key":"e_1_2_15_105_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-6-18"},{"key":"e_1_2_15_106_1","doi-asserted-by":"publisher","DOI":"10.2310\/JIM.0b013e31819aaa76"},{"key":"e_1_2_15_107_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx700177j"},{"key":"e_1_2_15_108_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-06-0023"},{"key":"e_1_2_15_109_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-08-0498"},{"key":"e_1_2_15_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2012.70"},{"key":"e_1_2_15_111_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0735842100"},{"key":"e_1_2_15_112_1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3727\/0965040041292297","article-title":"The cellular response to PPARgamma ligands is related to the phenotype of neuroblastoma cell lines","volume":"14","author":"Servidei T.","year":"2004","journal-title":"Oncol. Res."},{"key":"e_1_2_15_113_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.4301"},{"key":"e_1_2_15_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20346"},{"key":"e_1_2_15_115_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.1.36-45.2004"},{"key":"e_1_2_15_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.07.035"},{"key":"e_1_2_15_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12107"},{"key":"e_1_2_15_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/47520"},{"key":"e_1_2_15_119_1","first-page":"4844","article-title":"15\u2010deoxy\u2010delta 12,14\u2010prostaglandin J2 inhibits multiple steps in the NF\u2010kappa B signaling pathway","volume":"97","author":"Straus D.S.","year":"2000","journal-title":"Methods Mol. Biol."},{"key":"e_1_2_15_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2012.02.004"},{"key":"e_1_2_15_121_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgm299"},{"key":"e_1_2_15_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.12.039"},{"key":"e_1_2_15_123_1","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1089\/ars.2012.4523","article-title":"The electrophile responsive proteome: integrating proteomics and lipidomics with cellular function","volume":"17","author":"Higdon A.N.","journal-title":"Antioxid. Redox. Signal."},{"key":"e_1_2_15_124_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-520-0_26"},{"key":"e_1_2_15_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2014.09.014"},{"key":"e_1_2_15_126_1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/glia.20467","article-title":"Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration","volume":"55","author":"Qin L.","journal-title":"Glia"},{"key":"e_1_2_15_127_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0291-y"},{"key":"e_1_2_15_128_1","first-page":"327089","article-title":"Lipopolysaccharide animal models for Parkinson's disease","volume":"2011","author":"Liu M.","year":"2011","journal-title":"Parkinsons Dis."},{"key":"e_1_2_15_129_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-5-37"},{"key":"e_1_2_15_130_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-87"},{"key":"e_1_2_15_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.06.049"},{"key":"e_1_2_15_132_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04220.x"},{"key":"e_1_2_15_133_1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1242\/dmm.002733","article-title":"Rats!","volume":"2","author":"Iannaccone P.M.","journal-title":"Dis. Model. Mech."},{"key":"e_1_2_15_134_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/845618"},{"key":"e_1_2_15_135_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e328342568a"},{"key":"e_1_2_15_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20231"},{"key":"e_1_2_15_137_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19981201)54:5<698::AID-JNR15>3.0.CO;2-5"},{"key":"e_1_2_15_138_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-013-9628-2"},{"key":"e_1_2_15_139_1","doi-asserted-by":"publisher","DOI":"10.1007\/0-387-30128-3_10"},{"key":"e_1_2_15_140_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161211795589355"},{"key":"e_1_2_15_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2229"},{"key":"e_1_2_15_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.11.002"},{"key":"e_1_2_15_143_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759091415593294"},{"key":"e_1_2_15_144_1","doi-asserted-by":"publisher","DOI":"10.1161\/hq1101.098488"},{"key":"e_1_2_15_145_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.109.061010"},{"key":"e_1_2_15_146_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-4-18"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnyas.12987","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nyas.12987","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T16:44:27Z","timestamp":1694450667000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1111\/nyas.12987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":145,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/nyas.12987"],"URL":"https:\/\/doi.org\/10.1111\/nyas.12987","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]}}}