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Transforming growth factor \u03b2 (TGF\u2010\u03b2) has been reported to play a role in subchondral bone pathology and articular cartilage degeneration during the progression of OA. In this study, we demonstrated that systemic use of a TGF\u2010\u03b2\u2013neutralizing antibody (1D11) attenuates OA progression by targeting subchondral bone pathological features in rodent OA models. Systemic administration of 1D11 preserves the subchondral bone microarchitecture, preventing articular cartilage degeneration by inhibition of excessive TGF\u2010\u03b2 activity, in both subchondral bone and the circulation. Moreover, the aberrant increases in the numbers of blood vessels, nestin<jats:sup>+<\/jats:sup> mesenchymal stromal\/stem cells, and osterix<jats:sup>+<\/jats:sup> osteoblast progenitors were normalized by 1D11 systemic injection. Thus, systemic neutralization of excessive TGF\u2010\u03b2 ligands effectively prevented OA progression in animal models, with promising clinical implications for OA treatment.<\/jats:p>","DOI":"10.1111\/nyas.13000","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T16:45:13Z","timestamp":1454431513000},"page":"53-64","source":"Crossref","is-referenced-by-count":74,"title":["Systemic neutralization of TGF\u2010\u03b2 attenuates osteoarthritis"],"prefix":"10.1111","volume":"1376","author":[{"given":"Liang","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Institute for Cell Engineering Johns Hopkins University  Baltimore Maryland"},{"name":"State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Tintani","sequence":"additional","affiliation":[{"name":"Department of 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