{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T15:36:10Z","timestamp":1768923370567,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,3,14]],"date-time":"2016-03-14T00:00:00Z","timestamp":1457913600000},"content-version":"vor","delay-in-days":73,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>To gain further insights into the effects of elevated cysteine levels on energy metabolism and the possible mechanisms underlying these effects, we conducted studies in cysteine dioxygenase (<jats:italic>Cdo1<\/jats:italic>)\u2013null mice. Cysteine dioxygenase (CDO) catalyzes the first step of the major pathway for cysteine catabolism. When CDO is absent, tissue and plasma cysteine levels are elevated, resulting in enhanced flux of cysteine through desulfhydration reactions. When <jats:italic>Cdo1<\/jats:italic>\u2010null mice were fed a high\u2010fat diet, they gained more weight than their wild\u2010type controls, regardless of whether the diet was supplemented with taurine. <jats:italic>Cdo1<\/jats:italic>\u2010null mice had markedly lower leptin levels, higher feed intakes, and markedly higher abundance of hepatic stearoyl\u2010CoA desaturase 1 (SCD1) compared to wild\u2010type control mice, and these differences were not affected by the fat or taurine content of the diet. Thus, reported associations of elevated cysteine levels with greater weight gain and with elevated hepatic <jats:italic>Scd1<\/jats:italic> expression are also seen in the <jats:italic>Cdo1<\/jats:italic>\u2010null mouse model. Hepatic accumulation of acylcarnitines suggests impaired mitochondrial \u03b2\u2010oxidation of fatty acids in <jats:italic>Cdo1<\/jats:italic>\u2010null mice. The strong associations of elevated cysteine levels with excess H<jats:sub>2<\/jats:sub>S production and impairments in energy metabolism suggest that H<jats:sub>2<\/jats:sub>S signaling could be involved.<\/jats:p>","DOI":"10.1111\/nyas.13021","type":"journal-article","created":{"date-parts":[[2016,3,20]],"date-time":"2016-03-20T10:55:57Z","timestamp":1458471357000},"page":"99-115","source":"Crossref","is-referenced-by-count":17,"title":["Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice"],"prefix":"10.1111","volume":"1363","author":[{"given":"Julie","family":"Niewiadomski","sequence":"first","affiliation":[{"name":"Division of Nutritional Sciences Cornell University  Ithaca New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James Q.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Nutritional Sciences Cornell University  Ithaca New 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