{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:16:41Z","timestamp":1792664201772,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T00:00:00Z","timestamp":1458518400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>Solid evidence has established the negative impact of high iron burden and related tissue damage on the outcome of hemopoietic stem cell transplantation for thalassemia major. Recent improvements in our knowledge of iron metabolism have been focused on elevated non\u2010transferrin\u2010bound iron and labile plasma\u00a0iron levels in the peritransplantation period as potential contributors to tissue toxicity and subsequent adverse transplant outcome. As mouse models have shown,\u00a0iron overload\u00a0can injure bone marrow hematopoiesis by increasing reactive oxygen species. The Pesaro experience, conducted in the deferoxamine\u2010only era, clearly defined three iron\u2010related factors (liver fibrosis, hepatomegaly, and quality of lifelong chelation) as significantly affecting transplant outcome. The detrimental effect of iron has only been clarified in recent years. Active interventional strategies are ongoing. Although successful hematopoietic stem cell transplantation clinically resolves the thalassemia marrow defect, patients still remain carriers of iron overload and of all the clinical complications acquired during prior years of transfusion therapy. Therefore, adequate \u201ciron diagnosis\u201d and management is mandatory after hemopoietic stem cell transplantation. In transplanted thalassemia patients, body iron should be returned to within the normal range. Phlebotomy is the gold standard to reduce iron burden; though deferoxamine is a proven, acceptable alternative, clinical investigations on deferasirox are ongoing.<\/jats:p>","DOI":"10.1111\/nyas.13027","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T02:18:40Z","timestamp":1458613120000},"page":"115-121","source":"Crossref","is-referenced-by-count":41,"title":["Management of iron overload before, during, and after hematopoietic stem cell transplantation for thalassemia major"],"prefix":"10.1111","volume":"1368","author":[{"given":"Emanuele","family":"Angelucci","sequence":"first","affiliation":[{"name":"Unit\u00e0 Operativa Ematologia e Centro Trapianti, Ospedale Oncologico di Riferimento Regionale \u201cArmando Businco,\u201d Azienda Ospedaliera di Rilievo Nazionale \u201cBrotzu,\u201d  Cagliari 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