{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:07:08Z","timestamp":1792796828113,"version":"4.5.0"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T00:00:00Z","timestamp":1457654400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Alzheimer's Drug Discovery Foundation and the National Institutes of Health\/National Institute on Aging","award":["R01AG043679, PP-AG14930"],"award-info":[{"award-number":["R01AG043679, PP-AG14930"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>The earliest and perhaps best example of an interaction between nutrition and dementia is related to thiamine (vitamin B1). Throughout the last century, research showed that thiamine deficiency is associated with neurological problems, including cognitive deficits and encephalopathy. Multiple similarities exist between classical thiamine deficiency and Alzheimer's disease (AD) in that both are associated with cognitive deficits and reductions in brain glucose metabolism. Thiamine\u2010dependent enzymes are critical components of glucose metabolism that are reduced in the brains of AD patients and by thiamine decline, and a decrease in their levels could account for the reduction in glucose metabolism. In preclinical models, reduced thiamine can drive AD\u2010like abnormalities, including memory deficits, neuritic plaques, and hyperphosphorylation of tau. Furthermore, excess thiamine diminishes AD\u2010like pathologies. In addition to dietary deficits, drugs or other manipulations that interfere with thiamine absorption can cause thiamine deficiency. Elucidating the reasons why the brains of AD patients are functionally thiamine deficient and determining the effects of thiamine restoration may provide critical information to help treat patients with AD.<\/jats:p>","DOI":"10.1111\/nyas.13031","type":"journal-article","created":{"date-parts":[[2016,3,13]],"date-time":"2016-03-13T04:06:23Z","timestamp":1457841983000},"page":"21-30","source":"Crossref","is-referenced-by-count":204,"title":["Vitamin B1 (thiamine) and dementia"],"prefix":"10.1111","volume":"1367","author":[{"given":"Gary E.","family":"Gibson","sequence":"first","affiliation":[{"name":"Brain and Mind Research Institute, Weill Cornell Medical College, New York, New York, and Burke Medical Research Institute White Plains New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Burke Rehabilitation Hospital White Plains New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Fonzetti","sequence":"additional","affiliation":[{"name":"Burke Rehabilitation Hospital White Plains New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry D.","family":"Jordan","sequence":"additional","affiliation":[{"name":"Burke Rehabilitation Hospital White Plains New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna T.","family":"Cirio","sequence":"additional","affiliation":[{"name":"Burke Rehabilitation Hospital White Plains New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Elder","sequence":"additional","affiliation":[{"name":"Brain and Mind Research Institute, Weill Cornell Medical College, New York, New York, and Burke Medical Research Institute White Plains New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,11]]},"reference":[{"key":"e_1_2_16_2_1","volume-title":"The Wernicke\u2013Korsakoff Syndrome","author":"Victor M.","year":"1989"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1940.00190160002001"},{"key":"e_1_2_16_4_1","first-page":"117","article-title":"Frontal dysfunction and memory deficits in the alcoholic Korsakoff syndrome and Alzheimer\u2010type dementia","volume":"114","author":"Kopelman M.","year":"1991","journal-title":"Brain"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70223-4"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.003"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.1804"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.1721"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0720751.x"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-12-04183.2001"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08538"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.03.011"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-9452(08)70876-1"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1987.6"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520320022009"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013616"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI101296"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020678912330"},{"key":"e_1_2_16_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20474"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(00)00248-3"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(94)00162-9"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(05)80155-X"},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2006.03.004"},{"key":"e_1_2_16_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(86)90056-2"},{"key":"e_1_2_16_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)91243-0"},{"key":"e_1_2_16_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2007.08.014"},{"key":"e_1_2_16_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)28025-8"},{"key":"e_1_2_16_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(87)90037-6"},{"key":"e_1_2_16_29_1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0022-3565(25)32570-X","article-title":"Impairment of behavior and acetylcholine metabolism in thiamine deficiency","volume":"217","author":"Barclay L.L.","year":"1981","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_16_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1993.tb07457.x"},{"key":"e_1_2_16_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1993.tb03635.x"},{"key":"e_1_2_16_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2003.09.008"},{"key":"e_1_2_16_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.12.013"},{"key":"e_1_2_16_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.01.005"},{"key":"e_1_2_16_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq069"},{"key":"e_1_2_16_36_1","first-page":"71","article-title":"Nonalcoholic thiamine\u2010related encephalopathy (Wernicke\u2013Korsakoff syndrome) among inpatients with cancer: a series of 18 cases","volume":"57","author":"Elie I.\u2010G.","year":"2015","journal-title":"Psychosomatics"},{"key":"e_1_2_16_37_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.8.2110"},{"key":"e_1_2_16_38_1","unstructured":"Kennedy A.R.2001.The potential role of thiamine in the pathogenesis and treament of Alzheimer's disease. M.S. dissertation.University of Manitoba Winnipeg."},{"key":"e_1_2_16_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197712222972503"},{"key":"e_1_2_16_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2210-8-10"},{"key":"e_1_2_16_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1976.00500110027005"},{"key":"e_1_2_16_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/59.3.207"},{"key":"e_1_2_16_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65602-7"},{"key":"e_1_2_16_44_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M600418200"},{"key":"e_1_2_16_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2012.09.001"},{"key":"e_1_2_16_46_1","doi-asserted-by":"publisher","DOI":"10.1159\/000177659"},{"key":"e_1_2_16_47_1","first-page":"319","article-title":"Comparative bioavailability of two vitamin B1 preparations: benfotiamine and thiamine mononitrate","volume":"52","author":"Schreeb K.H.","year":"1997","journal-title":"Eur. J. Clin. Pharmacol"},{"key":"e_1_2_16_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2011.08304.x"},{"key":"e_1_2_16_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(84)90673-7"},{"key":"e_1_2_16_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-010-0242-z"},{"key":"e_1_2_16_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep12583"},{"key":"e_1_2_16_52_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520320019008"},{"key":"e_1_2_16_53_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1991.00530130093025"},{"key":"e_1_2_16_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/089198879300600408"},{"key":"e_1_2_16_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02080934"},{"key":"e_1_2_16_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0013-7006(07)91552-3"},{"key":"e_1_2_16_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2008.10.008"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnyas.13031","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nyas.13031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T15:26:48Z","timestamp":1748791608000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1111\/nyas.13031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/nyas.13031"],"URL":"https:\/\/doi.org\/10.1111\/nyas.13031","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3]]}}}