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This gap may be potentially addressed by several endoscopic and laparoscopic techniques, including gastric bypass surgery for those patients who are obese. These novel techniques do not significantly alter the anatomy of the esophagogastric junction, minimizing short\u2010 and long\u2010term adverse effects. This review provides an overview of the assessment of patients with refractory GERD and highlights the strengths and weaknesses of these minimally invasive therapies.<\/jats:p>","DOI":"10.1111\/nyas.13104","type":"journal-article","created":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T17:46:17Z","timestamp":1467827177000},"page":"14-20","source":"Crossref","is-referenced-by-count":12,"title":["How can we deal with the GERD treatment gap?"],"prefix":"10.1111","volume":"1381","author":[{"given":"George","family":"Triadafilopoulos","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology and Department of Surgery Stanford University School of Medicine  Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Azagury","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology and Department of Surgery Stanford University School of Medicine  Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/gou061"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/dote.12103"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00936.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dote.12423"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2007.01.023"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3324-y"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e32832c1504"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.179"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129689-200212000-00001"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2050.2012.01381.x"},{"key":"e_1_2_8_12_1","first-page":"107","article-title":"Treatment of Barrett's esophagus: update on new endoscopic surgical modalities","volume":"70","author":"Kristo I.","year":"2015","journal-title":"Minerva Chir"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i24.7730"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLE.0b013e3182582e92"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-010-1528-6"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.10.009"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-14-174"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-014-3731-3"},{"key":"e_1_2_8_19_1","first-page":"346","article-title":"Anti\u2010reflux mucosectomy for gastroesophageal reflux disease in the absence of hiatus hernia: a pilot study","volume":"27","author":"Inoue H.","year":"2014","journal-title":"Ann. 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