{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:59:19Z","timestamp":1791406759683,"version":"4.3.3"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T00:00:00Z","timestamp":1466035200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5U01NS58087"],"award-info":[{"award-number":["5U01NS58087"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:p>Cyanide is a metabolic poison that inhibits the utilization of oxygen to form ATP. The consequences of acute cyanide exposure are severe; exposure results in loss of consciousness, cardiac and respiratory failure, hypoxic brain injury, and dose\u2010dependent death within minutes to hours. In a mass\u2010casualty scenario, such as an industrial accident or terrorist attack, currently available cyanide antidotes would leave many victims untreated in the short time available for successful administration of a medical countermeasure. This restricted therapeutic window reflects the rate\u2010limiting step of intravenous administration, which requires both time and trained medical personnel. Therefore, there is a need for rapidly acting antidotes that can be quickly administered to large numbers of people. To meet this need, our laboratory is developing sulfanegen, a potential antidote for cyanide poisoning with a novel mechanism based on 3\u2010mercaptopyruvate sulfurtransferase (3\u2010MST) for the detoxification of cyanide. Additionally, sulfanegen can be rapidly administered by intramuscular injection and has shown efficacy in many species of animal models. This article summarizes the journey from concept to clinical leads for this promising cyanide antidote.<\/jats:p>","DOI":"10.1111\/nyas.13114","type":"journal-article","created":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T21:30:00Z","timestamp":1466112600000},"page":"202-209","source":"Crossref","is-referenced-by-count":25,"title":["Development of sulfanegen for mass cyanide casualties"],"prefix":"10.1111","volume":"1374","author":[{"given":"Steven E.","family":"Patterson","sequence":"first","affiliation":[{"name":"Center for Drug Design, Academic Health Center the University of Minnesota  Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryant","family":"Moeller","sequence":"additional","affiliation":[{"name":"Center for Drug Design, Academic Health Center the University of Minnesota  Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert T.","family":"Nagasawa","sequence":"additional","affiliation":[{"name":"Center for Drug Design, Academic Health Center the University of Minnesota  Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Vince","sequence":"additional","affiliation":[{"name":"Center for Drug Design, Academic Health Center the University of Minnesota  Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daune L.","family":"Crankshaw","sequence":"additional","affiliation":[{"name":"Center for Drug Design, Academic Health Center the University of Minnesota  Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacquie","family":"Briggs","sequence":"additional","affiliation":[{"name":"Center for Drug Design, Academic Health Center the University of Minnesota  Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Stutelberg","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry South Dakota State University  Brookings South Dakota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chakravarthy V.","family":"Vinnakota","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry South Dakota State University  Brookings South Dakota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Logue","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry South Dakota State University  Brookings South Dakota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2012.746424"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650802559632"},{"key":"e_1_2_8_4_1","volume-title":"Monterey WMD Terrorism Database","author":"Anonymous","year":"2015"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00424-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199112193252502"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/073490418800600303"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/20024091064246"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/106002809202600413"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90006-O"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(86)80131-7"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.6.921"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/01.paf.0000160680.08769.54","article-title":"Pseudolaminar necrosis in cyanide intoxication: a neuropathology case report","volume":"26","author":"Riudavets M.A.","year":"2005","journal-title":"Am. 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