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Therefore, we present new techniques in the assessment of esophageal function and the potential role of the mucosal barrier in the generation and propagation of pain. We discuss the assessment and role of esophageal sphincters in nociception, as well as imaging and electrophysiological techniques, with examples of their use in understanding the sensory system following noxious stimuli to the esophagus. Additionally, we discuss the mechanisms behind functional diseases of the esophagus. We conclude that the new methods have identified many of the mechanisms behind malfunction of the mucosa, disturbances of muscular and sphincter functions, and the central response to different stimuli. Taken together, this has increased our understanding of esophageal disorders and may lead to new treatment modalities.<\/jats:p>","DOI":"10.1111\/nyas.13175","type":"journal-article","created":{"date-parts":[[2016,9,6]],"date-time":"2016-09-06T14:43:18Z","timestamp":1473172998000},"page":"78-90","source":"Crossref","is-referenced-by-count":3,"title":["Neurophysiology and new techniques to assess esophageal sensory function: an update"],"prefix":"10.1111","volume":"1380","author":[{"given":"Christina","family":"Brock","sequence":"first","affiliation":[{"name":"Mech\u2010Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital and Clinical Institute Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard W.","family":"McCallum","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Texas Tech University Health Sciences Center  El Paso Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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