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Large blisters often manifest in skin, while the cornea develops microblisters, and, when enough form, the epithelium sloughs. If the exposure is severe, healing can be imperfect and can result in long\u2010term adverse consequences. For the cornea, this could manifest as recurrent corneal erosions. Since the corneal epithelial\u2013stromal separations are in the region identified by electron microscopy as the lamina lucida, the same region affected by the blistering disease junctional epidermolysis bullosa (JEB), we postulated that the molecules that are defective in JEB would be the same ones cleaved by mustard compounds. These molecules are \u03b16\u03b24 integrin and collagen XVII, which can be cleaved by matrix metalloproteinase\u20109 (MMP\u20109) and ADAM17, respectively. Therefore, our laboratory has tested MMP\u20109 and ADAM17 inhibitors as potential therapies to attenuate corneal mustard injury. Our results demonstrated that inhibiting MMP\u20109 and ADAM17 resulted in less epithelial\u2013stromal separation in the corneas at 24 h postexposure, as compared with using only medium as a therapy.<\/jats:p>","DOI":"10.1111\/nyas.13226","type":"journal-article","created":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T02:54:33Z","timestamp":1476413673000},"page":"158-165","source":"Crossref","is-referenced-by-count":18,"title":["The molecules in the corneal basement membrane zone affected by mustard exposure suggest potential therapies"],"prefix":"10.1111","volume":"1378","author":[{"given":"Marion K.","family":"Gordon","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy Rutgers University  Piscataway New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"DeSantis\u2010Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy Rutgers University  Piscataway New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Hahn","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy Rutgers University  Piscataway New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peihong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy Rutgers University  Piscataway New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yokechen","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy Rutgers University  Piscataway New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy K. H.","family":"Svoboda","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Baylor College of Dentistry Texas A&amp;M Health Science Center  Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald R.","family":"Gerecke","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy Rutgers University  Piscataway New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2013.06.013"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012374484-5.00039-0"},{"key":"e_1_2_7_4_1","unstructured":"The Guardian.2015.UN watchdog confirms mustard gas attack in Syria Organisation for the prohibition of chemical weapons says child was probably filled by mustard gas in August during fighting between jihadi and rebels. 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