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The IL\u201036 subfamily consists of three ligands\u2014IL\u201036\u03b1, IL\u201036\u03b2, and IL\u201036\u03b3\u2014and the natural antagonist IL\u201036Ra. The cytokines exert their effects through a specific IL\u201036 receptor consisting of IL\u201036R and IL\u20101RAcP chains. IL\u201036 cytokines can direct both innate and adaptive immune responses by acting on parenchymal, stromal, and specific immune cell subsets. In humans, inactivating mutations in the gene encoding the IL\u201036R antagonist, which lead to unregulated IL\u201036R signaling, lead to an autoinflammatory condition termed deficiency of the IL\u201036R antagonist, which primarily manifests as a severe form of pustular psoriasis. While such discoveries have prompted deeper mechanistic studies highlighting the important role of IL\u201036 cytokines in psoriatic skin inflammation, it is now evident that IL\u201036 cytokines can also play important roles in inflammatory disorders in other organs, such as the gastrointestinal tract and the lungs. Given these emerging roles, strategies to specifically target the expression and activity of the IL\u201036 family have the potential to uncover novel therapeutic approaches aimed at treating inflammatory diseases in humans.<\/jats:p>","DOI":"10.1111\/nyas.13280","type":"journal-article","created":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T18:46:47Z","timestamp":1477507607000},"page":"23-34","source":"Crossref","is-referenced-by-count":65,"title":["The emergence of the IL\u201036 cytokine family as novel targets for inflammatory diseases"],"prefix":"10.1111","volume":"1417","author":[{"given":"Patrick T.","family":"Walsh","sequence":"first","affiliation":[{"name":"National Children's Research Centre Our Lady's Children's Hospital  Dublin Ireland"},{"name":"School of Medicine Trinity Biomedical Sciences Institute Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padraic G.","family":"Fallon","sequence":"additional","affiliation":[{"name":"National Children's Research Centre Our Lady's Children's Hospital  Dublin Ireland"},{"name":"School of Medicine Trinity Biomedical Sciences Institute Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.1440"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.2.1169"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.14.10308"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2000.6184"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200011)30:11<3299::AID-IMMU3299>3.0.CO;2-S"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(01)02040-3"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.3.1440"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1110-973"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1121534109"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400538"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132612"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.723064"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3RI1014-495R"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.653378"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2013.10.019"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300828"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1684\/ecn.2011.0288"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2002.6752"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/107999001753289505"},{"key":"e_1_2_9_21_1","first-page":"167","article-title":"New insights in the immunobiology of IL\u20101 family members","volume":"4","author":"de Veerdonk F.L.","year":"2013","journal-title":"Front. 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