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Flavonoids, such as anthocyanins and flavonols, which are commonly found in plant foods, have shown protective effects against Cd\u2010induced damage. The cytoprotective effects of flavonoids against Cd\u2010induced diseases are mainly attributable to three mechanisms. First, flavonoids clear reactive oxygen species, thereby reducing lipid peroxide production and improving the activity of antioxidation enzymes. Second, flavonoids chelate Cd, thus reducing the accumulation of Cd and altering the levels of other essential metal ions\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Third, flavonoids reduce DNA damage and inhibit apoptosis. In addition, flavonoids were found to inhibit inflammation and fibrosis and improve glycometabolism and the secretion of reproductive hormones. We introduce the daily dosage and absorption rate of flavonoids and then focus on their bioactive effects against Cd\u2010induced toxicity and reveal the underlying metabolic pathway, which provides a basis for further study of the nutritional prevention of Cd\u2010induced injury. In particular, a better understanding is needed of the structure\u2013activity relationship of flavonoids against Cd toxicity, which has not yet been reported.\n                  <\/jats:p>","DOI":"10.1111\/nyas.13344","type":"journal-article","created":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T18:19:06Z","timestamp":1492625946000},"page":"5-19","source":"Crossref","is-referenced-by-count":92,"title":["Cytoprotective effects of dietary flavonoids against cadmium\u2010induced toxicity"],"prefix":"10.1111","volume":"1398","author":[{"given":"Xia","family":"Li","sequence":"first","affiliation":[{"name":"Department of Food Science and Engineering Institute of Food Safety and Nutrition, Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinwei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Food Science and Engineering Institute of Food Safety and Nutrition, Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxia","family":"Sun","sequence":"additional","affiliation":[{"name":"Faculty of Chemical Engineering and Light Industry Guangdong University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuijuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Food Science and Engineering Institute of Food Safety and Nutrition, Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Food Science and Engineering Institute of Food Safety and Nutrition, Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingmin","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Food Science and Engineering Institute of Food Safety and Nutrition, Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Food Science and Engineering Institute of Food Safety and Nutrition, Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibin","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Food Science and Engineering Institute of Food Safety and Nutrition, Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2009.05.004"},{"key":"e_1_2_10_3_1","first-page":"222","article-title":"Research progress on intervention methods and mechanisms of cadmium toxic effects","volume":"41","author":"Li G.X.","year":"2014","journal-title":"China Occup. 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