{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:17:03Z","timestamp":1787015823193,"version":"build-2736575974"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,7,10]],"date-time":"2017-07-10T00:00:00Z","timestamp":1499644800000},"content-version":"vor","delay-in-days":39,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004733","name":"Universidade de Macau","doi-asserted-by":"publisher","award":["MYRG2016\u201000008\u2010ICMS\u2010QRCM"],"award-info":[{"award-number":["MYRG2016\u201000008\u2010ICMS\u2010QRCM"]}],"id":[{"id":"10.13039\/501100004733","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004733","name":"Universidade de Macau","doi-asserted-by":"publisher","award":["MYRG2016\u201000165\u2010ICMS\u2010QRCM"],"award-info":[{"award-number":["MYRG2016\u201000165\u2010ICMS\u2010QRCM"]}],"id":[{"id":"10.13039\/501100004733","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006469","name":"Fundo para o Desenvolvimento das Ci\u00eancias e da Tecnologia","doi-asserted-by":"publisher","award":["FDCT\u2010020\/2015\/A1"],"award-info":[{"award-number":["FDCT\u2010020\/2015\/A1"]}],"id":[{"id":"10.13039\/501100006469","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>\n                    Cucurbit[7]uril (CB[7]), belonging to the cucurbit[\n                    <jats:italic>n<\/jats:italic>\n                    ]uril family (CB[\n                    <jats:italic>n<\/jats:italic>\n                    ],\n                    <jats:italic>n<\/jats:italic>\n                    = 5\u20138, 10, or 13\u201315), may form host\u2013guest complexes with a variety of small molecules of biomedical interest. The physical and chemical properties of the complexed drugs are often improved as a result of this complexation, suggesting the potential application of CB[7] as a pharmaceutical excipient. This review has summarized the most recent research progress reported between 2011 and early 2017 regarding the biocompatibility of CB[7] and the influence of CB[7] on the stability, solubility, biouptake, and biological activities (including therapeutic efficacies and toxicities) of guest drug molecules. Through this systemic summary and analysis, we intend to stimulate further research efforts in this area and promote the use of CB[7] as an emerging pharmaceutical excipient to improve various properties of drug molecules (or active pharmaceutical ingredients).\n                  <\/jats:p>","DOI":"10.1111\/nyas.13376","type":"journal-article","created":{"date-parts":[[2017,7,10]],"date-time":"2017-07-10T16:15:15Z","timestamp":1499703315000},"page":"108-119","source":"Crossref","is-referenced-by-count":110,"title":["Cucurbit[7]uril: an emerging candidate for pharmaceutical excipients"],"prefix":"10.1111","volume":"1398","author":[{"given":"Kit Ieng","family":"Kuok","sequence":"first","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences University of Macau  Taipa Macau SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengke","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences University of Macau  Taipa Macau SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian W.","family":"Wyman","sequence":"additional","affiliation":[{"name":"Department of Chemistry Queen's University  Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruibing","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences University of Macau  Taipa Macau SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.198810211"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.198810093"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.198800891"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr500392w"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/js960213f"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1576"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.2010.01030.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00341"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470661345.smc056"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00273C"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201403107"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar500075g"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.01.015"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijch.201100040"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijch.201100033"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-015-0189-4"},{"key":"e_1_2_11_18_1","first-page":"100","article-title":"A cisplatin slow\u2010release hydrogel drug delivery system based on a formulation of the macrocycle cucurbit[7]uril, gelatin and polyvinyl alcohol","volume":"134","author":"Oun R.","year":"2014","journal-title":"J. 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