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Juzep, is a common traditional herbal medicine named <jats:italic>Ze Xie<\/jats:italic> in Chinese. RA is an important herbal component of a number of well\u2010known Chinese medicinal preparations. It has been used to treat various ailments, such as dysuria, edema, nephropathy, hyperlipidemia, and diabetes. A wide range of chemical compounds, mainly triterpenoids, sesquiterpenoids, and diterpenoids, have been isolated from RA; among which the protostane\u2010type triterpenoids, termed alisols, have attracted the most attention owing to their unique chemical structures and various biological activities. The extract and active compounds of RA possess a wide spectrum of pharmacological effects (e.g., diuretic, antimetabolic disorder, hepatoprotective, immunomodulatory, antiosteoporotic, anti\u2010inflammatory, antitumor, antibacterial, and antiviral activities). Previous toxicological evaluations indicated that the RA extracts are relatively safe and have no serious side effects within certain dose ranges. This paper reviews the up\u2010to\u2010date information on the ethnomedicinal application, phytochemistry, pharmacology, and toxicology of RA. This information will be useful for a better understanding of the therapeutic potential of RA.<\/jats:p>","DOI":"10.1111\/nyas.13381","type":"journal-article","created":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T19:30:11Z","timestamp":1498764611000},"page":"90-101","source":"Crossref","is-referenced-by-count":76,"title":["Therapeutic potential of Rhizoma Alismatis: a review on ethnomedicinal application, phytochemistry, pharmacology, and toxicology"],"prefix":"10.1111","volume":"1401","author":[{"given":"Le\u2010Le","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences University of Macau  Macao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Pharmacy Fujian University of Traditional Chinese Medicine  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Lian","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences University of Macau  Macao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuping","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences University of Macau  Macao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingqing","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Fujian University of Traditional Chinese Medicine  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6703-3120","authenticated-orcid":false,"given":"Jin\u2010Jian","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences University of Macau  Macao China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,29]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Flora of China","author":"Wang Q.","year":"2010"},{"key":"e_1_2_8_3_1","volume-title":"Sheng Nong Ben Cao Jing","author":"Gu G.","year":"2007"},{"key":"e_1_2_8_4_1","volume-title":"Pharmacopoeia of the People's Republic of China. 1","author":"Chinese Pharmacopoeia Commission","year":"2015"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.04.021"},{"key":"e_1_2_8_6_1","first-page":"183","article-title":"Formation and growth inhibition of calcium oxalate crystals by Takusha (Alismatis rhizoma)","volume":"13","author":"Suzuki K.","year":"1999","journal-title":"Scanning Microsc"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2012.06.012"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/817616"},{"key":"e_1_2_8_9_1","first-page":"89","article-title":"Tokishakuyakusan as a treatment for women's diseases","volume":"29","author":"Chung M.H.","year":"2012","journal-title":"J. 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