{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T20:44:53Z","timestamp":1785789893809,"version":"3.56.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T00:00:00Z","timestamp":1504051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010002","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST102\u20102311\u2010B\u2010038\u201000"],"award-info":[{"award-number":["MOST102\u20102311\u2010B\u2010038\u201000"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST103\u20102320\u2010B\u2010038\u2010050"],"award-info":[{"award-number":["MOST103\u20102320\u2010B\u2010038\u2010050"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Periodontitis is an inflammatory disease of the supporting tissues of the teeth induced by periodontopathic bacteria that results in the progressive destruction of periodontal tissues. Treatment of periodontitis is painful and time\u2010consuming. Recently, herbal medicines have been considered for use in treating inflammation\u2010related diseases, including periodontitis. Resveratrol and its derivative 2,3,5,4\u2032\u2010tetrahydroxystilbene\u20102\u2010<jats:italic>O<\/jats:italic>\u2010\u03b2\u2010glucoside (THSG), a polyphenol extracted from <jats:italic>Polygonum multiflorum<\/jats:italic>, have anti\u2010inflammatory properties and other medical benefits. Here, we highlight the importance of resveratrol and its glycosylated derivative as possible complementary treatments for periodontitis and their potential for development as innovative therapeutic strategies. In addition, we present evidence and discuss the mechanisms of action of resveratrol and THSG on periodontitis, focusing on <jats:italic>Porphyromonas gingivalis<\/jats:italic>\u2013induced inflammatory responses in human gingival fibroblasts and animal modeling of ligature\u2010induced periodontitis. We also illuminate the signal transduction pathways and the cytokines involved.<\/jats:p>","DOI":"10.1111\/nyas.13433","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T09:38:46Z","timestamp":1504172326000},"page":"101-108","source":"Crossref","is-referenced-by-count":56,"title":["Therapeutic applications of resveratrol and its derivatives on periodontitis"],"prefix":"10.1111","volume":"1403","author":[{"given":"Yu\u2010Tang","family":"Chin","sequence":"first","affiliation":[{"name":"Taipei Cancer Center Taipei Medical University  Taipei Taiwan"},{"name":"Department of Dentistry, Wan\u2010Fang Medical Center Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guei\u2010Yun","family":"Cheng","sequence":"additional","affiliation":[{"name":"Graduate Institute of Immunology, College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010Jung","family":"Shih","sequence":"additional","affiliation":[{"name":"Taipei Cancer Center Taipei Medical University  Taipei Taiwan"},{"name":"PhD Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Yu","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Dentistry, College of Oral Medicine Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan\u2010Jen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Dentistry Hsinchu MacKay Memorial Hospital  Hsinchu City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsuan\u2010Yu","family":"Lai","sequence":"additional","affiliation":[{"name":"PhD Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Whang\u2010Peng","sequence":"additional","affiliation":[{"name":"Taipei Cancer Center Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsien\u2010Chung","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry National Defense Medical Center and Tri\u2010Service General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Yang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Wan\u2010Fang Medical Center Taipei Medical University  Taipei Taiwan"},{"name":"School of Dentistry, College of Oral Medicine Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Earl","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Dentistry Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng\u2010Yuan","family":"Tang","sequence":"additional","affiliation":[{"name":"Pharmaceutical Research Institute Albany College of Pharmacy and Health Sciences  Albany New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung\u2010Yun","family":"Lin","sequence":"additional","affiliation":[{"name":"Taipei Cancer Center Taipei Medical University  Taipei Taiwan"},{"name":"PhD Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leroy F","family":"Liu","sequence":"additional","affiliation":[{"name":"Taipei Cancer Center Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1986.tb01485.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12010"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12002"},{"key":"e_1_2_10_5_1","first-page":"837","article-title":"Oral scurvy and periodontal disease","volume":"63","author":"Touyz L.Z.","year":"1997","journal-title":"J. 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