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Claudin\u20104 is regulated via various factors in normal epithelial cells and diseases. We found that claudin\u20104 was directly regulated via p63 (TAp63 and \u0394Np63) in human keratinocytes and nasal epithelial cells. In the epidermis of atopic dermatitis (AD), which contains \u0394Np63\u2010deficient keratinocytes, high expression of claudin\u20104 was observed. In primary keratinocytes, downregulation of \u0394Np63 by treatment with short interfering RNA (siRNA)\u2010p63 induced claudin\u20104 expression. In nasal epithelial cells in the context of rhinitis or nasal polyps, upregulation of TAp63 and downregulation of claudin\u20104 were observed. In primary nasal epithelial cells transfected with the human telomerase reverse transcriptase gene, knockdown of p63 by siRNAs induced claudin\u20104 expression. Taken together, these findings indicate that p63 is a negative regulator of claudin\u20104 expression. Understanding the regulation of claudin\u20104 via p63 in human epithelial cells may be important for developing therapies for allergies and drug delivery systems.<\/jats:p>","DOI":"10.1111\/nyas.13456","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T09:46:57Z","timestamp":1504172817000},"page":"25-31","source":"Crossref","is-referenced-by-count":10,"title":["Regulation of claudin\u20104 via p63 in human epithelial cells"],"prefix":"10.1111","volume":"1405","author":[{"given":"Takashi","family":"Kojima","sequence":"first","affiliation":[{"name":"Department of Cell Science Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Kohno","sequence":"additional","affiliation":[{"name":"Department of Cell Science Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terufumi","family":"Kubo","sequence":"additional","affiliation":[{"name":"Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yakuto","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Cell Science Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine  Sapporo Japan"},{"name":"Department of Otolaryngology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Kakuki","sequence":"additional","affiliation":[{"name":"Department of Cell Science Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine  Sapporo Japan"},{"name":"Department of Otolaryngology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akito","family":"Kakiuchi","sequence":"additional","affiliation":[{"name":"Department of Cell Science Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine  Sapporo Japan"},{"name":"Department of Otolaryngology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Kurose","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken\u2010ichi","family":"Takano","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Ogasawara","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazufumi","family":"Obata","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Miyata","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takumi","family":"Konno","sequence":"additional","affiliation":[{"name":"Department of Cell Science Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Ichimiya","sequence":"additional","affiliation":[{"name":"Department of Human Immunology Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Himi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Sapporo Medical University School of Medicine  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.123.6.1631"},{"key":"e_1_2_7_3_1","first-page":"L647","article-title":"Structure, function, and regulation of cellular tight junctions","volume":"262","author":"Schneeberger E.E.","year":"1992","journal-title":"Am. 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