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This response has been termed<jats:italic>homeostatic synaptic plasticity<\/jats:italic>. Despite the intense interest in homeostatic synaptic plasticity, little attention has been paid to its role in the prototypic synaptic disease, myasthenia gravis. In this review, we discuss mechanisms that have been shown to mediate homeostatic synaptic plasticity at the mammalian neuromuscular junction. A subset of these mechanisms have been shown to occur in myasthenia gravis. The homeostatic changes occurring in myasthenia gravis appear to involve the presynaptic nerve terminal and may even involve changes in the excitability of motor neurons within the spinal cord. The finding of presynaptic homeostatic synaptic plasticity in myasthenia gravis leads us to propose that changes in the motor unit in myasthenia gravis may be more widespread than previously appreciated.<\/jats:p>","DOI":"10.1111\/nyas.13472","type":"journal-article","created":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T16:52:36Z","timestamp":1507222356000},"page":"170-177","source":"Crossref","is-referenced-by-count":29,"title":["Homeostatic synaptic plasticity at the neuromuscular junction in myasthenia gravis"],"prefix":"10.1111","volume":"1412","author":[{"given":"Xueyong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Cell Biology and Physiology Wright State University Dayton Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark M.","family":"Rich","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Cell Biology and Physiology Wright State University Dayton Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2015.06.024"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1954.sp005129"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3875"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.01.022"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.81.2.275"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3252-04.2005"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1966.tb45474.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(91)90413-K"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/272641a0"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1982.242.5.C366"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.11.2138"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/372519a0"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.2741\/4532","article-title":"Trans\u2010synaptic homeostasis at the myasthenic neuromuscular junction","volume":"22","author":"Plomp J.J.","year":"2017","journal-title":"Front. 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