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Until recently, treatment options included only short\u2010term therapy (\u226412 weeks), and paths beyond that schedule were challenging, as knowledge of the biology of obesity was lacking. With increased recognition of obesity as a chronic, complex medical disease, newer agents have been approved as long\u2010term therapy, and the cornerstone of treatment is chronic behavior and lifestyle change. In the last decade, the Food and Drug Administration (FDA) has approved several new weight loss medications for the chronic management of obesity. In this review paper, we provide the latest updates on obesity pharmacotherapy. The main areas we will cover include (1) pharmacological management of obesity, (2) a review of FDA\u2010approved weight loss medications, (3) comanagement of obesity and its metabolic sequelae (type 2 diabetes mellitus, hypertension, and dyslipidemia), and (4) obesity\u2010centric prescribing for mental illness, neurological disorders, and contraceptive planning.<\/jats:p>","DOI":"10.1111\/nyas.13542","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T19:38:23Z","timestamp":1517254703000},"page":"106-119","source":"Crossref","is-referenced-by-count":88,"title":["Updates on obesity pharmacotherapy"],"prefix":"10.1111","volume":"1411","author":[{"given":"Amanda","family":"Velazquez","sequence":"first","affiliation":[{"name":"Bariatric Medicine and Internal Medicine Kaiser Permanente Medical Center  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline M.","family":"Apovian","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Diabetes, Nutrition and Weight Management, Boston Medical Center Boston University School of Medicine  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Understanding the American obesity epidemic.2016. 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