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Acute exposure can lead to neurological sequelae among survivors. A drug for treating neurological sequelae in survivors of acute H<jats:sub>2<\/jats:sub>S intoxication is needed. Using a novel mouse model we evaluated the efficacy of cobinamide (Cob) for increasing survival of, and reducing neurological sequalae in, mice exposed to sublethal doses of H<jats:sub>2<\/jats:sub>S. There were two objectives: (1) to determine the dose\u2013response efficacy of Cob and (2) to determine the effective therapeutic time window of Cob. To explore objective 1, mice were injected intramuscularly with Cob at 0, 50, or 100\u00a0mg\/kg at 2\u00a0min after H<jats:sub>2<\/jats:sub>S exposure. For objective 2, mice were injected intramuscularly with 100\u00a0mg\/kg Cob at 2, 15, and 30\u00a0min after H<jats:sub>2<\/jats:sub>S exposure. For both objectives, mice were exposed to 765\u00a0ppm of H<jats:sub>2<\/jats:sub>S gas. Cob significantly reduced H<jats:sub>2<\/jats:sub>S\u2010induced lethality in a dose\u2010dependent manner (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05). Cob\u2010treated mice exhibited significantly fewer seizures and knockdowns compared with the H<jats:sub>2<\/jats:sub>S\u2010exposed group. Cob also reversed H<jats:sub>2<\/jats:sub>S\u2010induced weight loss, behavioral deficits, neurochemical changes, cytochrome <jats:italic>c<\/jats:italic> oxidase enzyme inhibition, and neurodegeneration in a dose\u2010 and time\u2010dependent manner (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.01). Overall, these findings show that Cob increases survival and is neuroprotective in a mouse model of H<jats:sub>2<\/jats:sub>S\u2010induced neurological sequelae.<\/jats:p>","DOI":"10.1111\/nyas.13559","type":"journal-article","created":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T12:55:17Z","timestamp":1513256117000},"page":"61-78","source":"Crossref","is-referenced-by-count":22,"title":["Cobinamide is effective for treatment of hydrogen sulfide\u2013induced neurological sequelae in a mouse model"],"prefix":"10.1111","volume":"1408","author":[{"given":"Poojya","family":"Anantharam","sequence":"first","affiliation":[{"name":"Department of Veterinary Diagnostic and Production Animal Medicine Iowa State University  Ames Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth M.","family":"Whitley","sequence":"additional","affiliation":[{"name":"Pathogenesis LLC  Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belinda","family":"Mahama","sequence":"additional","affiliation":[{"name":"Department of Veterinary Diagnostic and Production Animal Medicine Iowa State University  Ames Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010Suk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Veterinary Diagnostic and Production Animal Medicine Iowa State University  Ames Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Souvarish","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Iowa State University  Ames Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Santana","sequence":"additional","affiliation":[{"name":"Department of Veterinary Diagnostic and Production Animal Medicine Iowa State University  Ames Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Iowa State University  Ames Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anumantha G.","family":"Kanthasamy","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Iowa State University  Ames Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthi","family":"Kanthasamy","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Iowa State University  Ames Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerry R.","family":"Boss","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California  San Diego San Diego, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilson K.","family":"Rumbeiha","sequence":"additional","affiliation":[{"name":"Department of Veterinary Diagnostic and Production Animal Medicine Iowa State University  Ames Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2014.990976"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep20831"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.201402082"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-62627-1.00008-1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.10355"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-198505000-00018"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00380773"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(86)80383-3"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph13101013"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAF.0b013e3182886d35"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-197902000-00008"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2010.508044"},{"key":"e_1_2_8_14_1","first-page":"286","article-title":"Inhalation of hydrogen sulphide: a case of subacute manifestations and long term sequelae","volume":"48","author":"Parra O.","year":"1991","journal-title":"Br. 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