{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:58:20Z","timestamp":1788818300616,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T00:00:00Z","timestamp":1513209600000},"content-version":"vor","delay-in-days":43,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A reduction in the burden of schistosomiasis is potentially achievable by integrating a schistosomiasis vaccine with current control measures. Here, we determine parasite\u2010specific <jats:italic>in vitro<\/jats:italic> responses of B, T, and NK cells from naive uninfected rhesus macaques to <jats:italic>Schistosoma mansoni<\/jats:italic> (Sm) egg (SmEA) and worm antigen (SmWA) preparations isolated from infected baboons. Pronounced B cell responses to SmEA and NK cell responses to both SmEA and SmWA were observed. High levels of IL\u20102 and IL\u201021 responses against Sm antigens were observed in T and non\u2010T cells of lymph nodes (LNs) and gut lamina propria\u2013derived lymphocytes (LPLs). Data analysis showed multifunctionality of LN\u2010derived CD4<jats:sup>+<\/jats:sup>, CD8<jats:sup>+<\/jats:sup>, and CD4<jats:sup>+<\/jats:sup>CD8<jats:sup>+<\/jats:sup> double positive T cells against either SmWA or SmWA+SmEA antigen preparations. Distinct SmEA\u2010specific multifunctional responses were observed in gut LPLs, suggesting simultaneous responses against egg antigens. These data provide insight into the immune effectors involved in schistosome responses by rhesus macaques.<\/jats:p>","DOI":"10.1111\/nyas.13565","type":"journal-article","created":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T12:55:17Z","timestamp":1513256117000},"page":"79-89","source":"Crossref","is-referenced-by-count":3,"title":["The self\u2010curing phenomenon of schistosome infection in rhesus macaques: insight from <i>in vitro<\/i> studies"],"prefix":"10.1111","volume":"1408","author":[{"given":"Workineh","family":"Torben","sequence":"first","affiliation":[{"name":"Tulane National Primate Research Center, TNPRC, Comparative Pathology\/Immunology Tulane University Health Sciences Center  Covington Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adebayo J.","family":"Molehin","sequence":"additional","affiliation":[{"name":"Center for Tropical Medicine and Infectious Diseases, Department of Internal Medicine Texas Tech University Health Sciences Center  Lubbock Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert V.","family":"Blair","sequence":"additional","affiliation":[{"name":"Tulane National Primate Research Center, TNPRC, Comparative Pathology\/Immunology Tulane University Health Sciences Center  Covington Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carys","family":"Kenway","sequence":"additional","affiliation":[{"name":"Tulane National Primate Research Center, TNPRC, Comparative Pathology\/Immunology Tulane University Health Sciences Center  Covington Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faith","family":"Shiro","sequence":"additional","affiliation":[{"name":"Tulane National Primate Research Center, TNPRC, Comparative Pathology\/Immunology Tulane University Health Sciences Center  Covington Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davis","family":"Roslyn","sequence":"additional","affiliation":[{"name":"Tulane National Primate Research Center, TNPRC, Comparative Pathology\/Immunology Tulane University Health Sciences Center  Covington Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bayissa","family":"Chala","sequence":"additional","affiliation":[{"name":"Department of Applied Biology, Adama Science and Technology University School of Applied Natural Sciences  Adama Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dereje","family":"Gutu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine Jimma University  Jimma Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Kebede","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics George Washington University  Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gul","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Biology Peru State College  Peru Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Tropical Medicine and Infectious Diseases, Department of Internal Medicine Texas Tech University Health Sciences Center  Lubbock Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pyone","family":"Aye","sequence":"additional","affiliation":[{"name":"Tulane National Primate Research Center, TNPRC, Comparative Pathology\/Immunology Tulane University Health Sciences Center  Covington Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh","family":"Mohan","sequence":"additional","affiliation":[{"name":"Tulane National Primate Research Center, TNPRC, Comparative Pathology\/Immunology Tulane University Health Sciences Center  Covington Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Lackner","sequence":"additional","affiliation":[{"name":"Tulane National Primate Research Center, TNPRC, Comparative Pathology\/Immunology Tulane University Health Sciences Center  Covington Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afzal A.","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Center for Tropical Medicine and Infectious Diseases, Department of Internal Medicine Texas Tech University Health Sciences Center  Lubbock Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61949-2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000412"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001445"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002106"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.03.014"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2009.11.012"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001321"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70099-2"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e328359f04a"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2009.11.001"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2014.06.002"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182013000231"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001549"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2005.01.001"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2010.00976.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2438"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00046-07"},{"key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4614-4726-9_1","article-title":"Innovation for the \u2018bottom 100 million\u2019: eliminating neglected tropical diseases in the Americas","volume":"764","author":"Hotez P.J.","year":"2013","journal-title":"Adv. Exp. Med. Biol."},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2013.0170"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir545"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-009-1646-z"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.13-0467"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.2016.1131127"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001564"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001704"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.10.027"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.09.026"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.01.040"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003730"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1086\/651147"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2011.01.010"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1969.11686603"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000290"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1967.16.620"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003925"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200207260-00005"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182097001091"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009868"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000086017"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13028-017-0310-3"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.10.055"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001456"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2008.01091.x"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2009.02.096"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2010.02.2266"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-014-3879-8"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2009.01181.x"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00631.x"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.26.021607.090316"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/35040504"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1077002"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.12.7867"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23917"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005754"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01793-16"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02128-16"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw467"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21060"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2016.123"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1004110"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnyas.13565","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nyas.13565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T14:16:36Z","timestamp":1694614596000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1111\/nyas.13565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/nyas.13565"],"URL":"https:\/\/doi.org\/10.1111\/nyas.13565","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11]]}}}