{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:41:18Z","timestamp":1792226478230,"version":"4.4.0"},"reference-count":102,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T00:00:00Z","timestamp":1517184000000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["T32 DK062707"],"award-info":[{"award-number":["T32 DK062707"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Diabetic foot ulcers (DFUs) are a serious complication of diabetes that results in significant morbidity and mortality. Mortality rates associated with the development of a DFU are estimated to be 5% in the first 12 months, and 5\u2010year morality rates have been estimated at 42%. The standard practices in DFU management include surgical debridement, dressings to facilitate a moist wound environment and exudate control, wound off\u2010loading, vascular assessment, and infection and glycemic control. These practices are best coordinated by a multidisciplinary diabetic foot wound clinic. Even with this comprehensive approach, there is still room for improvement in DFU outcomes. Several adjuvant therapies have been studied to reduce DFU healing times and amputation rates. We reviewed the rationale and guidelines for current standard of care practices and reviewed the evidence for the efficacy of adjuvant agents. The adjuvant therapies reviewed include the following categories: nonsurgical debridement agents, dressings and topical agents, oxygen therapies, negative pressure wound therapy, acellular bioproducts, human growth factors, energy\u2010based therapies, and systemic therapies. Many of these agents have been found to be beneficial in improving wound healing rates, although a large proportion of the data are small, randomized controlled trials with high risks of bias.<\/jats:p>","DOI":"10.1111\/nyas.13569","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T14:38:23Z","timestamp":1517236703000},"page":"153-165","source":"Crossref","is-referenced-by-count":792,"title":["Update on management of diabetic foot ulcers"],"prefix":"10.1111","volume":"1411","author":[{"given":"Estelle","family":"Everett","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes, &amp; Metabolism, Department of Medicine Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0210-655X","authenticated-orcid":false,"given":"Nestoras","family":"Mathioudakis","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, &amp; Metabolism, Department of Medicine Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13054"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00152192-200511000-00007"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-2189"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.06.003"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-0940-0"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2013.0518"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12391"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis346"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2694"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12220"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2707"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2015.10.002"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.825"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2253"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-2204"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2697"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000002686"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2006.09.024"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2017.06.004"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2015.1021780"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.13006"},{"key":"e_1_2_6_24_1","first-page":"CD010764","article-title":"Intensive versus conventional glycaemic control for treating diabetic foot ulcers","volume":"13","author":"Fernando M.E.","year":"2016","journal-title":"Cochrane Database Syst. 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