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In this review, we consider changes in architecture, porosity, and composition, including collagen structure, mineral composition, and crystal size. These factors all are known to vary with tissue and animal ages, and health status. Bone morphology and presence of microcracks, which also contribute to bone quality, will not be discussed in this review. Correlations with mechanical performance for collagen cross\u2010linking, crystallinity, and carbonate content are contrasted with mineral content. Age\u2010dependent changes in humans and rodents are discussed in relation to rodent models of disease. Examples are osteoporosis, osteomalacia, osteogenesis imperfecta (OI), and osteopetrosis in both humans and animal models. Each of these conditions, along with aging, is associated with increased fracture risk for distinct reasons.<\/jats:p>","DOI":"10.1111\/nyas.13572","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T03:50:53Z","timestamp":1514001053000},"page":"93-106","source":"Crossref","is-referenced-by-count":166,"title":["Bone quality changes associated with aging and disease: a review"],"prefix":"10.1111","volume":"1410","author":[{"given":"Adele L.","family":"Boskey","sequence":"first","affiliation":[{"name":"Mineralized Tissue Laboratory, Hospital for Special Surgery  New York New York"},{"name":"Department of Biochemistry Weill Cornell Medical College  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurianne","family":"Imbert","sequence":"additional","affiliation":[{"name":"Mineralized Tissue Laboratory, Hospital for Special Surgery  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-007-0793-5"},{"issue":"5","key":"e_1_2_7_3_1","first-page":"S118","article-title":"Bone quality: where do we go from here","volume":"14","author":"Bouxsein M.L.","year":"2008","journal-title":"Osteoporos. 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