{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T02:03:43Z","timestamp":1769306623956,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T00:00:00Z","timestamp":1516752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our objective here was to determine whether oral bisphosphonate (BP) use is associated with the incidence of age\u2010related macular degeneration (AMD). We performed a population\u2010based study using electronic health records from UK primary care (Clinical Practice Research Datalink). A cohort of 13,974 hip fracture patients (1999\u20132013) was used to conduct (1) a propensity score\u2013matched cohort analysis and (2) a nested case\u2013control analysis. Hip fracture patients were aged \u226550 years without AMD diagnosis before hip fracture date or in the first year of follow\u2010up. Among 6208 matched patients and during 22,142 person\u2010years of follow\u2010up, 57 (1.8%) and 42 (1.4%) AMD cases occurred in BP users and non\u2010BP users, respectively. The survival analysis model did not provide significant evidence of a higher risk of AMD in BP users (subhazard ratio: 1.60; 95% confidence interval (CI): 0.95\u20132.72; <jats:italic>P<\/jats:italic> = 0.08), although there was a significant increased risk among BP users with high medication possession ratio (MPR) (top quartile) relative to non\u2010BP users (odds ratio: 5.08, 95% CI: 3.11\u20138.30; <jats:italic>P<\/jats:italic> &lt; 0.001, respectively). Overall, oral BP use was not associated with an increased risk of AMD in this cohort of hip fracture patients, although the risk increased significantly with higher MPR. More data are needed to confirm these findings.<\/jats:p>","DOI":"10.1111\/nyas.13589","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T12:33:38Z","timestamp":1516797218000},"page":"34-46","source":"Crossref","is-referenced-by-count":6,"title":["Oral bisphosphonate use and age\u2010related macular degeneration: retrospective cohort and nested case\u2013control study"],"prefix":"10.1111","volume":"1415","author":[{"given":"Cesar","family":"Garriga","sequence":"first","affiliation":[{"name":"Oxford NIHR Biomedical Research Centre, Musculoskeletal Theme, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Nuffield Orthopaedic Centre University of Oxford  Oxford UK"},{"name":"Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Nuffield Orthopaedic Centre University of Oxford  Oxford 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