{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:59:42Z","timestamp":1760889582348,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T00:00:00Z","timestamp":1520294400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/15864\u20103"],"award-info":[{"award-number":["2014\/15864\u20103"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Energy deprivation leads to a decrease in white adipose tissue and bone mineral density (BMD), while simultaneously inducing the expansion of marrow adipose tissue (MAT). In short bowel syndrome (SBS), parenteral nutrition mitigates the deterioration of nutritional status, including decreases in MAT. Osteoporosis is, however, a frequent complication of SBS. The objective of our study here was to evaluate the association of fat deposit sites (subcutaneous and visceral adipose tissues: intrahepatic lipid (IHL) and MAT) and the incretin glucagon\u2010like peptide 1 (GLP1) with BMD in individuals with SBS. MAT was negatively correlated with lumbar spine BMD in normal individuals, but not in those in the SBS group, who otherwise showed a positive correlation between MAT and GLP1. In addition, in individuals with SBS, IHL was negatively associated with lumbar spine BMD and positively associated with C\u2010terminal telopeptide of type 1 collagen (a serum biomarker of bone turnover). Caloric maintenance in individuals with SBS, therefore, seems to positively affect the relationship between MAT and BMD, which may be modulated, at least in part, by GLP1.<\/jats:p>","DOI":"10.1111\/nyas.13657","type":"journal-article","created":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T13:52:36Z","timestamp":1520344356000},"page":"47-56","source":"Crossref","is-referenced-by-count":7,"title":["Short bowel syndrome: influence of nutritional therapy and incretin GLP1 on bone marrow adipose tissue"],"prefix":"10.1111","volume":"1415","author":[{"given":"Luciana T.","family":"Parreiras\u2010e\u2010Silva","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Ribeirao Preto Medical School University of S\u00e3o Paulo (USP) S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iana M.","family":"de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ribeirao Preto Medical School University of S\u00e3o Paulo (USP) S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Jorge","family":"Elias","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ribeirao Preto Medical School University of S\u00e3o Paulo (USP) S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello H.","family":"Nogueira\u2010Barbosa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ribeirao Preto Medical School University of S\u00e3o Paulo (USP) S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian M.M.","family":"Suen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ribeirao Preto Medical School University of S\u00e3o Paulo (USP) S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio S.","family":"Marchini","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ribeirao Preto Medical School University of S\u00e3o Paulo (USP) S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9ssica","family":"Bonella","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ribeirao Preto Medical School University of S\u00e3o Paulo (USP) S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andressa K.","family":"Nahas","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Faculty of Public Health University of S\u00e3o Paulo (USP) S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos E.G.","family":"Salmon","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Philosophy, Sciences and Arts of Ribeir\u00e3o Preto University of S\u00e3o Paulo (USP) S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1262-3486","authenticated-orcid":false,"given":"Francisco J.A.","family":"de Paula","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ribeirao Preto Medical School University of S\u00e3o Paulo (USP) S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1097\/MCG.0000000000000512","article-title":"Intestinal failure: adaptation, rehabilitation, and transplantation","volume":"50","author":"Bharadwaj S.","year":"2016","journal-title":"J. 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