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The prevalence of both GERD and functional gastrointestinal disorders (FGIDs) ranges between 10% and 25% worldwide and there are distinct subgroups of patients with overlapping of GERD and FGIDs. However, the true prevalence of an overlap between GERD and FGIDs can be determined only when a formal pathophysiological evaluation has been performed. Nocturnal reflux symptoms have a significant impact on patients\u2019 sleep quality and quality of life. Although proton pump inhibitors (PPIs) can improve both reflux and sleep\u2010related symptoms, the relationship between nocturnal reflux events and sleep disturbance is not fully understood. GERD plays an important role in the pathogenesis of lung fibrosis, and PPIs or fundoplication may decrease the likelihood of pulmonary exacerbation or even improve pulmonary function. Refractory reflux symptoms without esophagitis have become one of the most common presentations of GERD in gastroenterology clinics. There are several new medical therapies, and endoscopic as well as laparoscopic techniques that have been increasingly used in these patients. The selection of options should be tailored and individualized based on the pathophysiology of refractory GERD.<\/jats:p>","DOI":"10.1111\/nyas.13850","type":"journal-article","created":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T08:47:56Z","timestamp":1526460476000},"page":"70-83","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Current and future perspectives in the management of gastroesophageal reflux disease"],"prefix":"10.1111","volume":"1434","author":[{"given":"Junichi","family":"Akiyama","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology National Center for Global Health and Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiko","family":"Kuribayashi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Integrative Center of Internal Medicine Gunma University Hospital Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myong Ki","family":"Baeg","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Catholic Kwandong University College of Medicine, International St. Mary's Hospital Incheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"de Bortoli","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elen","family":"Valitova","sequence":"additional","affiliation":[{"name":"Department of Upper Gastrointestinal Tract Disorders Clinical Scientific Centre Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edoardo V.","family":"Savarino","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology University of Padua Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoyasu","family":"Kusano","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Integrative Center of Internal Medicine Gunma University Hospital Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Triadafilopoulos","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University Stanford California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00630.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.08.002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2011.17.1.14"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06534.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30054-X"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.109413"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.1690"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355437"},{"key":"e_1_2_8_10_1","unstructured":"WHO.2007.WHO Expert Committee on problems related to alcohol consumption. 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