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As only 10% of GERD patients are finally treated by antireflux surgery, a large therapeutic window exists. This treatment gap consists of patients who are not effectively treated with proton pump inhibitor but do not want to run the potential risks of conventional surgery. During the last two decades, several novel and intriguing options for the surgical treatment of GERD have been introduced and found their way into clinical use. The following summary will give an update of certain alternative therapeutic options to treat GERD or its pathological consequences.<\/jats:p>","DOI":"10.1111\/nyas.13851","type":"journal-article","created":{"date-parts":[[2018,5,18]],"date-time":"2018-05-18T04:56:37Z","timestamp":1526619397000},"page":"360-369","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Alternative therapies for GERD: a way to personalized antireflux surgery"],"prefix":"10.1111","volume":"1434","author":[{"given":"Erwin","family":"Rieder","sequence":"first","affiliation":[{"name":"Department of Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Riegler","sequence":"additional","affiliation":[{"name":"Reflux Medical  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandar P.","family":"Simi\u0107","sequence":"additional","affiliation":[{"name":"University Hospital for Digestive Surgery, Clinical Center of Serbia University of Belgrade  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ognjan M.","family":"Skrobi\u0107","sequence":"additional","affiliation":[{"name":"University Hospital for Digestive Surgery, Clinical Center of Serbia University of Belgrade  Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Bonavina","sequence":"additional","affiliation":[{"name":"Division of General Surgery, Department of Biomedical Sciences for Health, University of Milano School of Medicine IRCCS Policlinico San Donato  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Gurski","sequence":"additional","affiliation":[{"name":"Department of Surgery, Universidade Federal do Rio Grande do Sul Hospital de Clinicas de Porto Alegre  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Paireder","sequence":"additional","affiliation":[{"name":"Department of Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald O.","family":"Castell","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Medical University of South Carolina  Charleston South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian F.","family":"Schoppmann","sequence":"additional","affiliation":[{"name":"Department of Surgery Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.051821"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-017-0712-6"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2015.02.010"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10353-016-0435-z"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10353-017-0494-9"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10353-017-0504-y"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00047.2007"},{"key":"e_1_2_11_9_1","first-page":"G117","article-title":"Mucosal integrity and sensitivity to acid in the proximal esophagus in patients with gastroesophageal reflux disease","volume":"311","author":"Hoeij F.B.","year":"2016","journal-title":"Am. 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