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Gonorrhea is typically treated with antibiotics; however, <jats:italic>N. gonorrhoeae<\/jats:italic> has rapidly acquired resistance to many antibiotic classes, and lineages with reduced susceptibility to the currently recommended therapies are emerging worldwide. In this review, we discuss the contributions of whole genome sequencing (WGS) to our understanding of resistant <jats:italic>N. gonorrhoeae<\/jats:italic>. Genomics has illuminated the evolutionary origins and population structure of <jats:italic>N. gonorrhoeae<\/jats:italic> and the magnitude of horizontal gene transfer within and between <jats:italic>Neisseria<\/jats:italic> species. WGS can be used to predict the susceptibility of <jats:italic>N. gonorrhoeae<\/jats:italic> based on known resistance determinants, track the spread of these determinants throughout the <jats:italic>N. gonorrhoeae<\/jats:italic> population, and identify novel loci contributing to resistance. WGS has also allowed more detailed epidemiological analysis of transmission of <jats:italic>N. gonorrhoeae<\/jats:italic> between individuals and populations than previously used typing methods. Ongoing <jats:italic>N. gonorrhoeae<\/jats:italic> genomics will complement other laboratory techniques to understand the biology and evolution of the pathogen, improve diagnostics and treatment in the clinic, and inform public health policies to limit the impact of antibiotic resistance.<\/jats:p>","DOI":"10.1111\/nyas.13871","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T05:36:56Z","timestamp":1528349816000},"page":"93-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Applications of genomics to slow the spread of multidrug\u2010resistant <i>Neisseria gonorrhoeae<\/i>"],"prefix":"10.1111","volume":"1435","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6255-690X","authenticated-orcid":false,"given":"Tatum D.","family":"Mortimer","sequence":"first","affiliation":[{"name":"Department of Immunology and Infectious Diseases Harvard T. H. Chan School of Public Health  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5646-1314","authenticated-orcid":false,"given":"Yonatan H.","family":"Grad","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases Harvard T. H. Chan School of Public Health  Boston Massachusetts"},{"name":"Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,6]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"CDC.2017. Gonorrhea\u20142016 STD surveillance report.November 22 2017. Accessed December 15 2017.https:\/\/www.cdc.gov\/std\/stats16\/Gonorrhea.htm."},{"key":"e_1_2_11_3_1","unstructured":"WHO.2012.Global action plan to control the spread and impact of antimicrobial resistance inNeisseria gonorrhoeae. 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