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Interoceptive mechanisms ensure physiological health through the cerebral coordination of homeostatic reflexes and allostatic responses that include motivational behaviors and associated affective and emotional feelings. Furthermore, the conscious, unitary sense of self in time and space may be grounded in the primacy and lifelong continuity of interoception. Body\u2010to\u2010brain interactions influence physical and mental well\u2010being. Consequently, we show that systematic investigation of how individual differences, and within\u2010individual changes, in interoceptive processing can contribute to the mechanistic understanding of physical and psychological disorders. We present a neurobiological overview of interoception and describe how interoceptive impairments at different levels relate to specific physical and mental health conditions, including sickness behaviors and fatigue, depression, eating disorders, autism, and anxiety. We frame these findings in an interoceptive predictive processing framework and highlight potential new avenues for treatments.\n                  <\/jats:p>","DOI":"10.1111\/nyas.13915","type":"journal-article","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T06:24:22Z","timestamp":1530771862000},"page":"112-128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":416,"title":["The neurobiology of interoception in health and disease"],"prefix":"10.1111","volume":"1428","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5896-916X","authenticated-orcid":false,"given":"Lisa","family":"Quadt","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Neuroscience, Brighton and Sussex Medical School (BSMS) Trafford Centre University of Sussex  Brighton United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo D.","family":"Critchley","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuroscience, Brighton and Sussex Medical School (BSMS) Trafford Centre University of Sussex  Brighton United Kingdom"},{"name":"Sackler Centre for Consciousness Science University of Sussex  Brighton United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah N.","family":"Garfinkel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuroscience, Brighton and Sussex Medical School (BSMS) Trafford Centre University of Sussex  Brighton United Kingdom"},{"name":"Sackler Centre for Consciousness Science University of Sussex  Brighton United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401510101"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3950"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963721414549350"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copsyc.2017.04.020"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780190217013.001.0001"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2787"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780199682737.001.0001"},{"key":"e_1_2_9_9_1","first-page":"395","article-title":"An interoceptive predictive coding model of conscious presence","volume":"2","author":"Seth A.K.","year":"2011","journal-title":"Front. 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