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The most common examples of thyroid diseases include hypothyroidism, hyperthyroidism, and several types of thyroid cancers. Phytochemicals have been shown to have either beneficial or detrimental effects on thyroid function. Some flavonoids have been reported to affect the expression and the activity of several thyroid\u2010related enzymes and proteins, and for this reason some concerns have been raised about the possible thyroid\u2010disruptive properties of foods enriched in these substances. On the other hand, the beneficial effects of some plant\u2010derived compounds, such as myricetin, quercetin, apigenin, rutin, genistein, and curcumin, and their possible role as adjuvants for the treatment of thyroid cancers have been described. Here, the role of phytochemicals in thyroid signaling modulation and their possible beneficial or detrimental effects on thyroid disease risk are discussed.<\/jats:p>","DOI":"10.1111\/nyas.13980","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T08:58:26Z","timestamp":1541062706000},"page":"3-19","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Effects of phytochemicals on thyroid function and their possible role in thyroid disease"],"prefix":"10.1111","volume":"1443","author":[{"given":"Francesca","family":"Pistollato","sequence":"first","affiliation":[{"name":"Center for Nutrition &amp; Health, CITICAN Universidad Europea del Atl\u00e1ntico, Parque Cient\u00edfico y Tecnol\u00f3gico de Cantabria  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Masias","sequence":"additional","affiliation":[{"name":"Center for Nutrition &amp; Health, CITICAN Universidad Europea del Atl\u00e1ntico, Parque Cient\u00edfico y Tecnol\u00f3gico de Cantabria  Santander Spain"},{"name":"\u00c1rea de Nutrici\u00f3n y Salud Universidad Internacional Iberoamericana (UNINI)  Campeche Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Agudo","sequence":"additional","affiliation":[{"name":"Center for Nutrition &amp; Health, CITICAN Universidad Europea del Atl\u00e1ntico, Parque Cient\u00edfico y Tecnol\u00f3gico de Cantabria  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Giampieri","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche, Sez, Biochimica Universit\u00e0 Politecnica delle Marche  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Battino","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche, Sez, Biochimica Universit\u00e0 Politecnica delle Marche  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2018.18"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2012.00094"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2011.06.074"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18061247"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.4065\/84.1.65"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldr030"},{"key":"e_1_2_11_8_1","unstructured":"Mayo Clinic Hypothyroidism (Underactive Thyroid). 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