{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:01:56Z","timestamp":1791684116334,"version":"4.3.4"},"reference-count":131,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T00:00:00Z","timestamp":1579046400000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:00:00Z","timestamp":1547510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012864","name":"Biomedical Research Institute of New Mexico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["nyaspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Receptor\u2010type protein tyrosine phosphatase, receptor type D (PTPRD) has likely roles as a neuronal cell adhesion molecule and synaptic specifier. Interest in its neurobiology and genomics has been stimulated by results from human genetics and mouse models for phenotypes related to addiction, restless leg syndrome, neurofibrillary pathology in Alzheimer's disease, cognitive impairment\/intellectual disability, mood lability, and obsessive\u2010compulsive disorder. We review PTPRD's discovery, gene family, candidate homomeric and heteromeric binding partners, phosphatase activities, brain distribution, human genetic associations with nervous system phenotypes, and mouse model data relevant to these phenotypes. We discuss the recently reported discovery of the first small molecule inhibitor of PTPRD phosphatase, the identification of its addiction\u2010related effects, and the implications of these findings for the PTPRD\u2010associated brain phenotypes. In assembling PTPRD neurobiology, human genetics, and mouse genetic and pharmacological datasets, we provide a compelling picture of the roles played by PTPRD, its variation, and its potential as a target for novel therapeutics.<\/jats:p>","DOI":"10.1111\/nyas.14002","type":"journal-article","created":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T06:09:28Z","timestamp":1547618968000},"page":"112-129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["PTPRD: neurobiology, genetics, and initial pharmacology of a pleiotropic contributor to brain phenotypes"],"prefix":"10.1111","volume":"1451","author":[{"given":"George R.","family":"Uhl","sequence":"first","affiliation":[{"name":"Neurology and Research Services New Mexico VA Healthcare System  Albuquerque New Mexico"},{"name":"Departments of Neurology, Neuroscience, Molecular Genetics\u00a0and\u00a0Microbiology University of New Mexico  Albuquerque New Mexico"},{"name":"Biomedical Research Institute of New Mexico  Albuquerque New Mexico"},{"name":"Departments of Neurology, Neuroscience\u00a0and\u00a0Mental Health Johns Hopkins Medical Institutions  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J.","family":"Martinez","sequence":"additional","affiliation":[{"name":"Neurology and Research Services New Mexico VA Healthcare System  Albuquerque New Mexico"},{"name":"Biomedical Research Institute of New Mexico  Albuquerque New Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.61.3.223"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1720446115"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1990.tb07523.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.13.9.5513"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.25.11686"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.12.6722"},{"key":"e_1_2_10_8_1","unstructured":"https:\/\/www.ncbi.nlm.nih.gov\/projects\/mapview\/maps.cgi?TAXID=9606&QUERY=PTPRD&chr=9&maps=genes-r&beg=8200000&end=10700000&links=off&verbose=on&compress=off&width=350&size=30. Accessed July 2016."},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12776"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1610155113"},{"key":"e_1_2_10_11_1","unstructured":"https:\/\/www.ncbi.nlm.nih.gov\/gene\/5789. Accessed July 2017."},{"key":"e_1_2_10_12_1","unstructured":"https:\/\/www.ncbi.nlm.nih.gov\/genome\/gdv\/browser\/?comtext=genome&acc=GCF_000001405.37A. Accessed November 2017."},{"key":"e_1_2_10_13_1","unstructured":"https:\/\/www.uniprot.org\/uniprot\/P23468. Accessed July 2017."},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.03.030"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2006-7-1-r5"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.22.8698"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1999.0789"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep09686"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3040"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6423"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4637-11.2012"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7926"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2279"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1178310"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1200840"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00105"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02417-z"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj20021962"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.07.002"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.5.2608"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205810200"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi401223r"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2016.03.003"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2980"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2519-16.2017"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199701)208:1<48::AID-AJA5>3.0.CO;2-1"},{"key":"e_1_2_10_37_1","unstructured":"http:\/\/mouse.brain-map.org\/experiment\/show?id=855."},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0223-0"},{"key":"e_1_2_10_39_1","unstructured":"http:\/\/hipposeq.janelia.org\/full\/t1\/C4D0A824-369B-11E8-874A-A4F501797C37\/."},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4216"},{"key":"e_1_2_10_41_1","unstructured":"http:\/\/casesstudies.brain-map.org\/celltax#section_explorea."},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.08.062"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.02.004"},{"key":"e_1_2_10_44_1","unstructured":"http:\/\/mouse.brain-map.org\/experiment\/show?id=1462. Accessed July 2017."},{"key":"e_1_2_10_45_1","unstructured":"http:\/\/mouse.brain-map.org\/experiments\/show?id=70278045. Accessed July 2017."},{"key":"e_1_2_10_46_1","unstructured":"http:\/\/mouse.brain-map.org\/experiment\/show?id=69874150. Accessed July 2017."},{"key":"e_1_2_10_47_1","unstructured":"http:\/\/mouse.brain-map.org\/experiment\/show?id=74882837. Accessed July 2017."},{"key":"e_1_2_10_48_1","unstructured":"http:\/\/mouse.brain-map.org\/experiment\/show?id=69874144. Accessed July 2017."},{"key":"e_1_2_10_49_1","unstructured":"https:\/\/www.ncbi.nlm.gov\/projects\/SNP\/snp_ref.cgi?rs=10977171. Accessed July 2017."},{"key":"e_1_2_10_50_1","unstructured":"https:\/\/www.ncbi.nlm.nih.gov\/projects\/SNP\/snp-ref.cgi?rs=35929428. Accessed July 2017."},{"key":"e_1_2_10_51_1","unstructured":"http:\/\/dgv.tcag.ca\/gb2\/gbrowse.dgv2_hg19\/?name=id:2888025;dbid=gene:database. Accessed July 2017."},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.2217\/bmm-2018-0020"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2015.00017"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evy054"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3698"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500329102"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300855"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09797"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.165738"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30436"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.31143"},{"key":"e_1_2_10_62_1","unstructured":"Abstracts 2017.World Congress of Psychiatric Genetics Orlando Fla. (#1602)."},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.290"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2156-8-10"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.65.6.683"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042646"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2010.01152.x"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.190"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23459"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.3200"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.4006"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1086\/420772"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102415620907"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2012.03.012"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12337"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2010.087858"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2015.03.010"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2016.06.003"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsmc.2018.02.005"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.14.5274"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.20"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-017-0787-1"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20042"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-017-0012-7"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2013.75"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2015.52"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2017.61"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2010.128"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13977"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2014.43"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.154"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10519"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1086\/423899"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11689-016-9170-9"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13039-015-0149-0"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.244"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.11.028"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.12.2775"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0386-06.2006"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4531-04.2005"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2007.00070.x"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2017.0027"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2013.06.002"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.05.022"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2008.06.014"},{"key":"e_1_2_10_106_1","first-page":"1385","article-title":"Synthesis and LAR inhibition of 7\u2010alkoxy analogues of illudalic acid","volume":"45","author":"Ling Q.","year":"2010","journal-title":"Yao Xue Xue Bao"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2015.00170"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds221"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.030080"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.20"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2018.1417379"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10090314"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-17-0733"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1445"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.23909"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.22000"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgx089"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176045"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-16-0522"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14678"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-02-696757"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13284"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2015.0010"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1401952111"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22630"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2012.09.094"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.3109\/07357907.2012.675383"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-3272"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12017"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41397-018-0049-x"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-018-1921-1"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.14"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnyas.14002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nyas.14002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nyas.14002","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/am-pdf\/10.1111\/nyas.14002","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nyas.14002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T19:45:08Z","timestamp":1694288708000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1111\/nyas.14002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,15]]},"references-count":131,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/nyas.14002"],"URL":"https:\/\/doi.org\/10.1111\/nyas.14002","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,15]]},"assertion":[{"value":"2018-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}