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An abundance of evidence from a range of hematological malignancies supports the concept that the niche also participates in the pathogenesis of malignant hematopoiesis, differentially supporting malignant stem or progenitor cells over that of normal blood cell development. In 2005, patients with myeloproliferative neoplasms were reported to harbor an acquired, activating, missense V617F mutation of the cytokine\u2010signaling Janus kinase (JAK)\u20102, JAK2<jats:sup>V617F<\/jats:sup>, present in virtually all patients with polycythemia vera and half of patients with essential thrombocythemia and primary myelofibrosis. Using both <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> methods, several investigators have shown that in addition to driving cytokine\u2010independent proliferation in HSCs, JAK2<jats:sup>V617F<\/jats:sup> contributes to these neoplasms by altering the hematopoietic niche. The role of both endothelial cells and megakaryocytes bearing JAK2<jats:sup>V617F<\/jats:sup> will be presented, which involves altering cytokine production within the niche, resulting in their differential support of mutant kinase\u2013bearing stem cells over their normal counterparts, and imparting relative radiation resistance to stem cells. The clinical correlates of these findings will be discussed, as will their therapeutic implications.<\/jats:p>","DOI":"10.1111\/nyas.14028","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T07:18:50Z","timestamp":1550215130000},"page":"17-23","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The marrow stem cell niche in normal and malignant hematopoiesis"],"prefix":"10.1111","volume":"1466","author":[{"given":"Kenneth","family":"Kaushansky","sequence":"first","affiliation":[{"name":"Stony Brook University School of Medicine  Stony Brook New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huichun","family":"Zhan","sequence":"additional","affiliation":[{"name":"Stony Brook University School of Medicine  Stony Brook New 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