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OT also plays a key role in social bonding, which involves an interaction between OT and dopamine (DA) in the nucleus accumbens (NAc). The nature of the interaction between OT and DA in the striatum in the context of psychostimulants is unclear. We investigated the effect of OT, delivered intraperitoneally, on the methylphenidate (MP) dose\u2013response function for self\u2010administration in rats. Food was used as a control condition. In a microdialysis study, we measured the effect of intraperitoneal OT on MP\u2010stimulated striatal DA levels. Systemic OT pretreatment caused a downward shift in the MP dose\u2013response function for self\u2010administration, while having no effect on motor activity. OT also caused a reduction in food self\u2010administration, although a significantly higher dose of OT was required for this effect compared with that required for a reduction of MP self\u2010administration. Systemic OT pretreatment caused a potentiation of MP\u2010stimulated DA levels in the NAc shell but not in the core. The significance of these findings is discussed, including the potential of OT as a therapeutic agent for addictive disorders.<\/jats:p>","DOI":"10.1111\/nyas.14101","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T07:16:15Z","timestamp":1557472575000},"page":"173-184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of systemically administered oxytocin on dose response for methylphenidate self\u2010administration and mesolimbic dopamine levels"],"prefix":"10.1111","volume":"1455","author":[{"given":"Mary R.","family":"Lee","sequence":"first","affiliation":[{"name":"Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism, Division of Intramural Clinical and Basic Research and National Institute on Drug Abuse Intramural Research Program National Institutes of Health  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.H.","family":"Rohn","sequence":"additional","affiliation":[{"name":"Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism, Division of Intramural Clinical and Basic Research and National Institute on Drug Abuse Intramural Research Program National Institutes of Health  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Zanettini","sequence":"additional","affiliation":[{"name":"Medications Development Program, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse Intramural Research Program National Institutes of Health  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Coggiano","sequence":"additional","affiliation":[{"name":"Medications Development Program, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse Intramural Research Program National Institutes of Health  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Leggio","sequence":"additional","affiliation":[{"name":"Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism, Division of Intramural Clinical and Basic Research and National Institute on Drug Abuse Intramural Research Program National Institutes of Health  Bethesda Maryland"},{"name":"Medications Development Program, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse Intramural Research Program National Institutes of Health  Baltimore Maryland"},{"name":"Center for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences Brown University  Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Tanda","sequence":"additional","affiliation":[{"name":"Medications Development Program, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse Intramural Research Program National Institutes of Health  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1845"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.11.030"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12518"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.06.003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7071605"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.12.6661"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05721.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(86)90168-1"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4530(92)90073-G"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(03)00555-4"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3044"},{"key":"e_1_2_7_13_1","first-page":"65","article-title":"Drugs of abuse: biochemical surrogates of specific aspects of natural reward?","volume":"59","author":"Di Chiara G.","year":"1993","journal-title":"Biochem. 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