{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:50:48Z","timestamp":1793040648680,"version":"4.5.0"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T00:00:00Z","timestamp":1560902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FOR2149"],"award-info":[{"award-number":["FOR2149"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Project 7"],"award-info":[{"award-number":["Project 7"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EN 453\/10\u20101"],"award-info":[{"award-number":["EN 453\/10\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FOR2149"],"award-info":[{"award-number":["FOR2149"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Project 7"],"award-info":[{"award-number":["Project 7"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EN 453\/10\u20102"],"award-info":[{"award-number":["EN 453\/10\u20102"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["nyaspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    GPR126 (ADGRG6) is an adhesion G protein\u2013coupled receptor that plays an important role in a variety of tissues\/organs, such as heart, sciatic nerve, cartilage, and ear. Moreover,\n                    <jats:italic>GPR126<\/jats:italic>\n                    (\n                    <jats:italic>ADGRG6<\/jats:italic>\n                    ) mutations are associated with human diseases, like adolescent idiopathic scoliosis, lung disease, bladder cancer, and intellectual disability. Despite its clinical importance, it remains elusive how GPR126 is activated and mediates signal transduction and what cellular processes depend on GPR126 signaling. Here, we generated a\n                    <jats:italic>lacZ<\/jats:italic>\n                    reporter mouse line to determine endogenous\n                    <jats:italic>Gpr126<\/jats:italic>\n                    (\n                    <jats:italic>Adgrg6<\/jats:italic>\n                    ) expression in a cell type\u2010specific manner during embryonic development, at postnatal day 5 and in adult animals. Our results confirm\n                    <jats:italic>Gpr126<\/jats:italic>\n                    expression data previously obtained utilizing antibodies and\n                    <jats:italic>in situ<\/jats:italic>\n                    hybridization in embryonic heart and sciatic nerve. In addition, we provide data with cellular resolution for previously described RT\u2010PCR\u2013based data, including lung and bladder. Moreover, new\n                    <jats:italic>Gpr126<\/jats:italic>\n                    \u2010expressing tissues and cell types were identified, such as ureter and acinar secretory cells. Collectively, our data demonstrate that the newly generated\n                    <jats:italic>lacZ<\/jats:italic>\n                    reporter mouse is a suitable model to study\n                    <jats:italic>Gpr126<\/jats:italic>\n                    expression during development and adulthood, provide detailed insight into\n                    <jats:italic>Gpr126<\/jats:italic>\n                    expression at the cellular level, and reveal that all identified\n                    <jats:italic>Gpr126<\/jats:italic>\n                    \u2010expressing cells are known to be exposed to mechanical stimuli.\n                  <\/jats:p>","DOI":"10.1111\/nyas.14135","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T08:24:11Z","timestamp":1560932651000},"page":"96-108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["<i>Gpr126 (Adgrg6)<\/i>\n                    is expressed in cell types known to be exposed to mechanical stimuli"],"prefix":"10.1111","volume":"1456","author":[{"given":"Gentian","family":"Musa","sequence":"first","affiliation":[{"name":"Experimental Renal and Cardiovascular Research, Department of Nephropathology Institute of Pathology, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Cazorla\u2010V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Experimental Renal and Cardiovascular Research, Department of Nephropathology Institute of Pathology, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Machteld J.","family":"van Amerongen","sequence":"additional","affiliation":[{"name":"Department of Cardiac Development and Remodelling Max\u2010Planck\u2010Institute for Heart and Lung Research  Bad Nauheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc P.","family":"Stemmler","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine I, Nikolaus\u2010Fiebiger\u2010Center Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Eckstein","sequence":"additional","affiliation":[{"name":"Department of Pathology and Anatomy Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arndt","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Department of Pathology and Anatomy Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Braun","sequence":"additional","affiliation":[{"name":"Department of Cardiac Development and Remodelling Max\u2010Planck\u2010Institute for Heart and Lung Research  Bad Nauheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Brabletz","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine I, Nikolaus\u2010Fiebiger\u2010Center Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2605-3429","authenticated-orcid":false,"given":"Felix B.","family":"Engel","sequence":"additional","affiliation":[{"name":"Experimental Renal and Cardiovascular Research, Department of Nephropathology Institute of Pathology, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"},{"name":"Department of Cardiac Development and Remodelling Max\u2010Planck\u2010Institute for Heart and Lung Research  Bad Nauheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.114.009647"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1304837110"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1809-13.2013"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3854-15.2016"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1173474"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.062224"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.12.057"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv170"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.098061"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.40531"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-18-0363"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2639"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-29011-7"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.04.014"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2017.10.001"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.500"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9658"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-015-0364-0"},{"key":"e_1_2_7_20_1","first-page":"79","article-title":"The multiple signaling modalities of adhesion G protein\u2010coupled receptor GPR126 in development","volume":"1","author":"Patra C.","year":"2014","journal-title":"Receptors Clin. Investig"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1356-9597.2004.00743.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.05.038"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2005347"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature19312"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.763656"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.11.036"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014047"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.093401"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2014.11.009"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000002123"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00327.2009"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05760513"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.08880914"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/wsbm.1212"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800043-4.00011-7"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-9-43"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.08.040"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.061192"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2016.03.004"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI83083"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12725"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1159\/000087983"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22629"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.38889"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00282.2013"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-23115-w"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00260.2004"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00456.2014"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.105445"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198870070-00006"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI34174"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4316"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00414"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.BRS.0000134567.52303.1A"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517708766"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04194-9"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnyas.14135","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nyas.14135","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nyas.14135","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nyas.14135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T09:27:23Z","timestamp":1694165243000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1111\/nyas.14135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,19]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1111\/nyas.14135"],"URL":"https:\/\/doi.org\/10.1111\/nyas.14135","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,19]]},"assertion":[{"value":"2019-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}