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Resistance to multiple \u03b2\u2010lactams complicates effective clinical management of CRE infections. Using plasmid typing methods, a wide distribution of plasmid replicon groups has been reported in CREs around the world, including IncF, N, X, A\/C, L\/M, R, P, H, I, and W. We performed a literature search for English research papers, published between 2013 and 2018, reporting on plasmid\u2010mediated carbapenem resistance. A rise in both carbapenemase types and associated plasmid replicon groups was seen, with China, Canada, and the United States recording a higher increase than other countries. <jats:italic>bla<\/jats:italic><jats:sub>KPC<\/jats:sub> was the most prevalent, except in Angola and the Czech Republic, where OXA\u2010181 (<jats:italic>n<\/jats:italic>\u00a0=\u00a050, 88%) and OXA\u201048\u2013like (<jats:italic>n<\/jats:italic>\u00a0=\u00a024, 44%) carbapenemases were most prevalent, respectively; <jats:italic>bla<\/jats:italic><jats:sub>KPC\u20102\/3<\/jats:sub> accounted for 70% (<jats:italic>n<\/jats:italic>\u00a0=\u00a0956) of all reported carbapenemases. IncF plasmids were found to be responsible for disseminating different antibiotic resistance genes worldwide, accounting for almost 40% (<jats:italic>n<\/jats:italic>\u00a0=\u00a0254) of plasmid\u2010borne carbapenemases. <jats:italic>bla<\/jats:italic><jats:sub>CTX\u2010M<\/jats:sub>, <jats:italic>bla<\/jats:italic><jats:sub>TEM<\/jats:sub>, <jats:italic>bla<\/jats:italic><jats:sub>SHV<\/jats:sub>, <jats:italic>bla<\/jats:italic><jats:sub>OXA\u20101\/9<\/jats:sub>, <jats:italic>qnr<\/jats:italic>, and <jats:italic>aac\u2010(6\u2032)\u2010lb<\/jats:italic> were mostly detected concurrently with carbapenemases. Most reported plasmids were conjugative but not present in multiple countries or species, suggesting limited interspecies and interboundary transmission of a common plasmid. A major limitation to effective characterization of plasmid evolution was the use of PCR\u2010based instead of whole\u2010plasmid sequencing\u2013based plasmid typing.<\/jats:p>","DOI":"10.1111\/nyas.14223","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T13:11:20Z","timestamp":1567170680000},"page":"61-91","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":228,"title":["Plasmid evolution in carbapenemase\u2010producing <i>Enterobacteriaceae<\/i>: a review"],"prefix":"10.1111","volume":"1457","author":[{"given":"Katlego","family":"Kopotsa","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Health Sciences, School of Medicine University of Pretoria  Pretoria Gauteng South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9508-984X","authenticated-orcid":false,"given":"John","family":"Osei 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