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Due to growing concerns about the substantial risks of long\u2010term opioid use, both governmental agencies and professional societies have recommended prioritizing the use of nonpharmacologic treatments, when suitable, in order to reduce or eliminate the need for opioid use. The use of 10\u00a0kHz spinal cord stimulation (10\u00a0kHz SCS) is one such nonpharmacologic alternative for the treatment of chronic, intractable pain of the trunk and limbs. This review examines published clinical data regarding the efficacy of 10\u00a0kHz SCS for decreasing chronic pain in patients and its potential to reduce or eliminate opioid usage. Multiple prospective and retrospective studies in patients with intractable pain demonstrated that 10\u00a0kHz SCS treatment provided \u226550% pain relief in &gt;70% patients after at least 1 year of treatment. Pain relief with 10\u00a0kHz SCS therapy ranged from 54% to 87% in the studies. More importantly, the mean daily dose of opioids required by patients in these studies was reduced after 10\u00a0kHz SCS treatment, and on average over 60% patients in studies either reduced or eliminated opioids at the last follow\u2010up.<\/jats:p>","DOI":"10.1111\/nyas.14236","type":"journal-article","created":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T05:20:18Z","timestamp":1570080018000},"page":"53-64","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Opioid\u2010sparing effects of 10\u00a0kHz spinal cord stimulation: a review of clinical evidence"],"prefix":"10.1111","volume":"1462","author":[{"given":"Adnan","family":"Al\u2010Kaisy","sequence":"first","affiliation":[{"name":"The Pain Management and Neuromodulation Centre Guy's and St. Thomas\u2019 Hospital  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Pierre","family":"Van Buyten","sequence":"additional","affiliation":[{"name":"Multidisciplinary Pain Centre AZ Nikolaas  St Niklaas Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasra","family":"Amirdelfan","sequence":"additional","affiliation":[{"name":"IPM Medical Group, Inc.  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