{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T20:59:16Z","timestamp":1779224356913,"version":"3.51.4"},"reference-count":209,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T00:00:00Z","timestamp":1571788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["nyaspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nitric oxide (NO), a small molecule generated ubiquitously, targets a plethora of tissues to regulate both physiological and pathophysiological functions. NO overproduction, stimulated by microenvironmental conditions, is the main component that dysregulates the tight balance between its beneficial and damaging roles in ocular homeostasis. Considering the protective functions of NO against glaucoma, its endogenous release facilitates aqueous humor drainage and regulates ocular blood flow, maintaining a normal intraocular pressure. NO overproduction generates free radicals, such as peroxynitrite, which induce a vicious circle of vascular disharmony and dysregulation, transient ischemia, nitrosative stress, neuronal degeneration, and permanent glaucomatic injury.<jats:italic>Helicobacter pylori<\/jats:italic>(<jats:italic>Hp<\/jats:italic>) is considered a burdening factor of glaucoma. NO overproduction and possible systematic dispersion in<jats:italic>Hp<\/jats:italic>infection (<jats:italic>Hp<\/jats:italic>\u2010I) could suggest a potential pathophysiological bridge between these conditions. In this review, we aim to elucidate the role of NO in glaucoma with respect to<jats:italic>Hp<\/jats:italic>\u2010I, with the aim to stimulate further studies.<\/jats:p>","DOI":"10.1111\/nyas.14253","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T09:50:46Z","timestamp":1571824246000},"page":"10-28","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Impact of nitric oxide's bidirectional role on glaucoma: focus on<i>Helicobacter pylori<\/i>\u2013related nitrosative stress"],"prefix":"10.1111","volume":"1465","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3563-4973","authenticated-orcid":false,"given":"Apostolis","family":"Papaefthymiou","sequence":"first","affiliation":[{"name":"Department of Gastroenterology 401 General Military Hospital of Athens Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0396-5081","authenticated-orcid":false,"given":"Michael","family":"Doulberis","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University of Zurich Zurich Switzerland"},{"name":"Department of Internal Medicine, Second Medical Clinic, Ippokration Hospital Aristotle University of Thessaloniki Thessaloniki Macedonia Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9693-3846","authenticated-orcid":false,"given":"Panagiotis","family":"Katsinelos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Second Medical Clinic, Ippokration Hospital Aristotle University of Thessaloniki Thessaloniki Macedonia Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8025-0808","authenticated-orcid":false,"given":"Christos","family":"Liatsos","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology 401 General Military Hospital of Athens Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9232-4042","authenticated-orcid":false,"given":"Stergios A.","family":"Polyzos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Second Medical Clinic, Ippokration Hospital Aristotle University of Thessaloniki Thessaloniki Macedonia Greece"},{"name":"First Department of Pharmacology, School of Medicine Aristotle University of Thessaloniki Thessaloniki Macedonia Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3767-6365","authenticated-orcid":false,"given":"Georgios","family":"Kotronis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Agios Pavlos General Hospital Thessaloniki Macedonia Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4336-7270","authenticated-orcid":false,"given":"Katerina","family":"Papanikolaou","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Second Medical Clinic, Ippokration Hospital Aristotle University of Thessaloniki Thessaloniki Macedonia Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6459-5136","authenticated-orcid":false,"given":"Jannis","family":"Kountouras","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Second Medical Clinic, Ippokration Hospital Aristotle University of Thessaloniki Thessaloniki Macedonia Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,23]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1","article-title":"Inducible nitric oxide inhibitor aminoguanidine, ameliorated oxidative stress, interleukin\u20106 concentration and improved brain\u2010derived neurotrophic factor in the brain tissues of neonates born from titanium dioxide nanoparticles exposed rats","volume":"7058","author":"Asghari A.","year":"2018","journal-title":"J. Matern. Neonatal Med."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1001-907"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.63.070194.001135"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2010.06.001"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2214"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00315.2016"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2018.10.019"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-018-0108-x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-017-0513-7"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-017-0094-6"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apha.2017.09.003"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3570593"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2007.01.004"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2018.02.017"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-007-0013-x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00048.2003"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.323"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11626"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-002-0559-7"},{"key":"e_1_2_8_21_1","first-page":"109","article-title":"Nitric oxide: physiology, pathophysiology, and pharmacology","volume":"43","author":"Moncada S.","year":"1991","journal-title":"Pharmacol. Rev."},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00175.2004"},{"key":"e_1_2_8_23_1","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/S0021-9258(17)42402-1","article-title":"Purification and reconstitution of the high\u2010conductance, calcium\u2010activated potassium channel from tracheal smooth muscle","volume":"269","author":"Garcia\u2010Calvo M.","year":"1994","journal-title":"J. Biol. Chem."},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.03988.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0157405"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-016-1931-z"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.01918.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0070-2137(96)80006-9"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1268"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000217632.98717.a0"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3192"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2016.05.012"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.5772\/52780"},{"key":"e_1_2_8_34_1","unstructured":"American Academy of Ophthalmology.Theories of glaucomatous optic nerve damage. Clinical education: basic & clinical science course.American Academy of Ophthalmology. Cited December 17 2016.https:\/\/www.aao.org\/bcscsnippetdetail.aspx?id=f19571e0-b8d7-4679-a2c5-fd30a9b016c1."},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(99)00015-4"},{"key":"e_1_2_8_36_1","first-page":"2515","article-title":"Relaxation of trabecular meshwork and ciliary muscle by release of nitric oxide","volume":"35","author":"Wiederholt M.","year":"1994","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(99)00026-0"},{"key":"e_1_2_8_38_1","first-page":"68","volume-title":"Nitric Oxide and Endothelin in the Pathogenesis of Glaucoma","author":"Wiederholt M.","year":"1998"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25305"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2750"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00363.2007"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(02)00008-3"},{"key":"e_1_2_8_43_1","first-page":"1411","article-title":"Enhanced expression of inducible nitric oxide synthase and nitrotyrosine in gastric mucosa of gastric cancer patients","volume":"5","author":"Goto T.","year":"1999","journal-title":"Clin. Cancer Res."},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70496-8"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.153601"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00347.2014"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-5072"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)61083-2"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)61095-9"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012435555-2\/50004-8"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.125.4.494"},{"key":"e_1_2_8_52_1","first-page":"1765","article-title":"Identification of an extensive system of nitric oxide\u2010producing cells in the ciliary muscle and outflow pathway of the human eye","volume":"36","author":"Nathanson J.A.","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(97)84043-X"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2013.10.011"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)91400-M"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14515"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.891177"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2008.150409"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(01)00014-3"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060156"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1363"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1997.01100150499009"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2007.01167.x"},{"key":"e_1_2_8_64_1","first-page":"CR501","article-title":"Assessment of blood flow in posterior ciliary arteries and its correlation with intraocular and arterial blood pressures in patients with open angle glaucoma","volume":"16","author":"Waliszek\u2010Iwanicka A.","year":"2010","journal-title":"Med. Sci. Monit."},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004170050377"},{"key":"e_1_2_8_66_1","first-page":"880","article-title":"Nonadrenergic, noncholinergic relaxation of bovine iris sphincter: role of endogenous nitric oxide","volume":"41","author":"Pianka P.","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_2_8_67_1","first-page":"2340","article-title":"Nitric oxide and endothelin\u20101 are important regulators of human ophthalmic artery","volume":"33","author":"Haefliger I.O.","year":"1992","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-7839"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-11491"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201604932"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.3341\/kjo.2012.26.2.123"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1097\/00061198-200206000-00012"},{"key":"e_1_2_8_73_1","first-page":"1771","article-title":"Phase III comparative clinical study on KT 210 in patients with primary open\u2010angle glaucoma and ocular hypertension\u2010multicenter cooperative between\u2010group comparative double\u2010blind clinical trial with 0.5% timolol maleate ophthalmic solution","volume":"13","author":"Masuda K.","year":"1996","journal-title":"J. Eye"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201801047"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2007.08.005"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2014.42"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4835(02)92029-4"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.04.026"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.17.9455"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.17.9944"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.92.428"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)83026-9"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199403033300907"},{"key":"e_1_2_8_84_1","first-page":"495","article-title":"Protective effect of magnesium acetyltaurate and taurine against NMDA\u2010induced retinal damage involves reduced nitrosative stress","volume":"24","author":"Jafri A.J.A.","year":"2018","journal-title":"Mol. Vis."},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6701967"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.5.852"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02153655"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.83.8.980"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(01)00198-9"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-013-9707-4"},{"key":"e_1_2_8_91_1","first-page":"1618","article-title":"Chronic low\u2010dose glutamate is toxic to retinal ganglion cells. Toxicity blocked by memantine","volume":"37","author":"Vorwerk C.K.","year":"1996","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20171246"},{"key":"e_1_2_8_93_1","first-page":"1177","article-title":"Neuroprotective effects of eliprodil in retinal excitotoxicity and ischemia","volume":"40","author":"Kapin M.A.","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_2_8_94_1","doi-asserted-by":"crossref","first-page":"864","DOI":"10.2460\/ajvr.1997.58.08.864","article-title":"Vitreous body glutamate concentration in dogs with glaucoma","volume":"58","author":"Brooks D.E.","year":"1997","journal-title":"Am. J. Vet. Res."},{"key":"e_1_2_8_95_1","first-page":"2633","article-title":"Vitreal glutamate concentration in monkeys with experimental glaucoma","volume":"43","author":"Carter\u2010Dawson L.","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2007.00529.x"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arteri.2016.04.002"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(03)00008-0"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00029.2006"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2005.06.001"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/364626a0"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.98106s51145"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(92)90433-W"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M208916200"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(19981001)43:1<75::AID-JEMT11>3.0.CO;2-0"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(91)90224-7"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2018.04.010"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.5772\/18513"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.117.11.1524"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-13699"},{"key":"e_1_2_8_111_1","first-page":"574","article-title":"The fine structure of the cribriform meshwork in normal and glaucomatous eyes as seen in tangential sections","volume":"21","author":"Rohen J.W.","year":"1981","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2008.11.025"},{"key":"e_1_2_8_113_1","volume-title":"Glaucoma \u2010 Current Clinical and Research Aspects","author":"Sacc\u00e0 S.C.","year":"2011"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702737"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8902"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000576"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105479"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000751"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4266"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1493-z"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2003.10.042"},{"key":"e_1_2_8_122_1","first-page":"4863","article-title":"Caffeic acid phenethyl ester attenuates nuclear factor\u2010KB\u2010mediated inflammatory responses in M\u00fcller cells and protects against retinal ganglion cell death","volume":"19","author":"Jia Y.","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1245132"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2005.10.021"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.06.002"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5873"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2003.07.005"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010716-105001"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-57193-5_16"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00011.2017"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2018.04.004"},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2018.09.104"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00351"},{"key":"e_1_2_8_134_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.174631"},{"key":"e_1_2_8_135_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13945"},{"key":"e_1_2_8_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.04.024"},{"key":"e_1_2_8_137_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12454"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.06.008"},{"key":"e_1_2_8_139_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare7010034"},{"key":"e_1_2_8_140_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12517"},{"key":"e_1_2_8_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2018.09.011"},{"key":"e_1_2_8_142_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000203644.68059.5f"},{"key":"e_1_2_8_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70247-3"},{"key":"e_1_2_8_144_1","first-page":"426","article-title":"Microbes and Alzheimer\u2019 disease: lessons from H. pylori and GUT microbiota","volume":"23","author":"Franceschi F.","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"e_1_2_8_145_1","first-page":"1275","article-title":"Epitope mapping of anti\u2010rhodopsin antibodies from patients with normal pressure glaucoma","volume":"40","author":"Romano C.","year":"1999","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"e_1_2_8_146_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.241443798"},{"key":"e_1_2_8_147_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4304"},{"key":"e_1_2_8_148_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.219"},{"key":"e_1_2_8_149_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.8548"},{"key":"e_1_2_8_150_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.12.6002"},{"key":"e_1_2_8_151_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12573"},{"key":"e_1_2_8_152_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006464"},{"key":"e_1_2_8_153_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.01918.x"},{"key":"e_1_2_8_154_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501062"},{"key":"e_1_2_8_155_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.13707"},{"key":"e_1_2_8_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.10.014"},{"key":"e_1_2_8_157_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.02368-14"},{"key":"e_1_2_8_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2006.10.022"},{"key":"e_1_2_8_159_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01940-06"},{"key":"e_1_2_8_160_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins8060187"},{"key":"e_1_2_8_161_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.11.043"},{"key":"e_1_2_8_162_1","first-page":"316","article-title":"Oxidative stress resulting from Helicobacter pylori infection contributes to gastric carcinogenesis","volume":"3","author":"Butcher L.D.","year":"2017","journal-title":"CMGH"},{"key":"e_1_2_8_163_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2004.00977.x"},{"key":"e_1_2_8_164_1","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.2000.0490"},{"key":"e_1_2_8_165_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0b013e3181fa0cf7"},{"key":"e_1_2_8_166_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.159046"},{"key":"e_1_2_8_167_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-003-0779-5"},{"key":"e_1_2_8_168_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-199310000-00002"},{"key":"e_1_2_8_169_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.117.7.917"},{"key":"e_1_2_8_170_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2010.87"},{"key":"e_1_2_8_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(03)00211-7"},{"key":"e_1_2_8_172_1","doi-asserted-by":"publisher","DOI":"10.4291\/wjgp.v5.i3.373"},{"key":"e_1_2_8_173_1","first-page":"120","article-title":"Serum TNF\u2010a, IL\u20108, VEGF levels in Helicobacter pylori infection and their association with degree of gastritis","volume":"47","author":"Siregar G.A.","year":"2015","journal-title":"Acta Med. Indones."},{"key":"e_1_2_8_174_1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3889\/oamjms.2017.031","article-title":"Serum VEGF levels in Helicobacter pylori infection and correlation with Helicobacter pylori cagA and vacA genes","volume":"5","author":"Siregar G.","year":"2017","journal-title":"Open Access Maced. J. Med. Sci."},{"key":"e_1_2_8_175_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1992.262.2.H611"},{"key":"e_1_2_8_176_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20181894"},{"key":"e_1_2_8_177_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000216"},{"key":"e_1_2_8_178_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000021125.83697.21"},{"key":"e_1_2_8_179_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2351-9"},{"key":"e_1_2_8_180_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/762514"},{"key":"e_1_2_8_181_1","doi-asserted-by":"publisher","DOI":"10.1086\/517814"},{"key":"e_1_2_8_182_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.2001.00042.x"},{"key":"e_1_2_8_183_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2009.00719.x"},{"key":"e_1_2_8_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2004.09.002"},{"key":"e_1_2_8_185_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.meg.0000252637.11291.1d"},{"key":"e_1_2_8_186_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2019.1591499"},{"key":"e_1_2_8_187_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703468"},{"key":"e_1_2_8_188_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715762.2016.1271122"},{"key":"e_1_2_8_189_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-35413"},{"key":"e_1_2_8_190_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-123-2-199507150-00005"},{"key":"e_1_2_8_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17179-1"},{"key":"e_1_2_8_192_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370218824340"},{"key":"e_1_2_8_193_1","first-page":"389","article-title":"The emerging role of Helicobacter pylori\u2010induced metabolic gastrointestinal dysmotility and neurodegeneration","volume":"17","author":"Kountouras J.","year":"2017","journal-title":"Curr. Mol. Med."},{"key":"e_1_2_8_194_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-21091"},{"key":"e_1_2_8_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.10.022"},{"key":"e_1_2_8_196_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.1.129"},{"key":"e_1_2_8_197_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-49-4-349"},{"key":"e_1_2_8_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.10.015"},{"key":"e_1_2_8_199_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-0323"},{"key":"e_1_2_8_200_1","doi-asserted-by":"publisher","DOI":"10.1159\/000330053"},{"key":"e_1_2_8_201_1","doi-asserted-by":"publisher","DOI":"10.1159\/000216353"},{"key":"e_1_2_8_202_1","first-page":"571","article-title":"Biological activity of Helicobacter pylori components in mammalian cells: is it independent of proteinase\u2010activated receptors?","volume":"63","author":"Sekiguchi F.","year":"2012","journal-title":"J. Physiol. Pharmacol."},{"key":"e_1_2_8_203_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180786"},{"key":"e_1_2_8_204_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2003.021"},{"key":"e_1_2_8_205_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.WCB.0000128266.87474.BF"},{"key":"e_1_2_8_206_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2235594100"},{"key":"e_1_2_8_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00598-4"},{"key":"e_1_2_8_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2003.09.014"},{"key":"e_1_2_8_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2003.11.013"},{"key":"e_1_2_8_210_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2008.01705.x"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nyas.14253","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nyas.14253","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nyas.14253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T13:20:49Z","timestamp":1721913649000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1111\/nyas.14253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,23]]},"references-count":209,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1111\/nyas.14253"],"URL":"https:\/\/doi.org\/10.1111\/nyas.14253","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,23]]},"assertion":[{"value":"2019-06-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}