{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:29:22Z","timestamp":1788560962020,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T00:00:00Z","timestamp":1571788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["nyaspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The field of regulatory peptide research has developed significant momentum owing to several recent converging trends. Dozens of peptide\u2010based drugs have been approved by the U.S. Food and Drug Administration in the past decade, the majority for the treatment of metabolic disorders, including diabetes. These are the \u201ctip of the spear\u201d for peptide therapeutics, revealing that impediments of delivery, stability, and bioavailability inherent in peptide drugs have in many cases been overcome. While most are orally available, and directed at peripheral targets, pharmaceutical delivery of peptides to the central nervous system through nasal mucosal routes has also seen much progress. Cell\u2010based high\u2010throughput drug discovery methods, the X\u2010ray crystallographic structural definition of G protein\u2013coupled receptors, and deorphanization of peptide\u2010liganded receptors have contributed to the emergence of new targets for pharmacological intervention and accelerated the development of peptide\u2010based as well as nonpeptide congeners for existing ones. Finally, the recognition that peptides act at their receptors, in a cellular context, in conjunction with other peptides and other first messengers, including neurotransmitters, hormones, and autocrine and paracrine factors, has led to an increased appreciation for the combinatorial possibilities of regulatory peptide action, now penetrating to drug design and discovery efforts. The fifteen reviews, reports, and perspectives collected in this special issue of <jats:italic>Annals of the New York Academy of Sciences<\/jats:italic> provide a snapshot of the frontiers of the field of regulatory peptide research as they expand physiologically, pharmacologically, and therapeutically.<\/jats:p>","DOI":"10.1111\/nyas.14260","type":"journal-article","created":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T05:23:25Z","timestamp":1571894605000},"page":"5-11","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Progress in regulatory peptide research"],"prefix":"10.1111","volume":"1455","author":[{"given":"Limei","family":"Zhang","sequence":"first","affiliation":[{"name":"Departmento de Fisiolog\u00eda, Facultad de Medicina Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM)  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee 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