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In order to exploit the immense therapeutic potential of PSA, previous studies have focused on the identification and development of peptide\u2010based or synthetic PSA mimetics. 5\u2010Nonyloxytryptamine (5\u2010NOT) has been previously reported as a PSA\u2010mimicking compound for promoting functional recovery after spinal cord injury in mice. In order to explore the neuroregeneration potential of 5\u2010NOT, the current study was based on a biomaterial approach using collagen\u2013laminin (C\/L) scaffolds. In<jats:italic>in vitro<\/jats:italic>studies, 5\u2010NOT was observed to promote neurite outgrowth, migration, and fasciculation in cerebellar neuronal cells, whereas in 3D cell cultures it showed more ramification and complex Sholl profiles. 5\u2010NOT promoted the survival and neurite length of cortical neurons when cocultured with glutamate\u2010challenged astrocytes. In<jats:italic>in vivo<\/jats:italic>studies, spinal cord compression injury mice were used with immediate application of C\/L hydrogels impregnated with 5\u2010NOT. C\/L + 5\u2010NOT\u2013treated mice demonstrated \u223c75% of motor recovery 14 days after injury. Furthermore, this effect was shown to be dependent on the ERK\u2013MAPK pathway and augmentation of cell survival. Thus, based on a biomaterial approach, our current study provides new insight for 5\u2010NOT\u2013containing hydrogels as a promising candidate to speed up recovery after central nervous system injuries.<\/jats:p>","DOI":"10.1111\/nyas.14279","type":"journal-article","created":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T10:42:10Z","timestamp":1575456130000},"page":"99-116","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["5\u2010Nonyloxytryptamine oxalate\u2013embedded collagen\u2013laminin scaffolds augment functional recovery after spinal cord injury in mice"],"prefix":"10.1111","volume":"1465","author":[{"given":"Shikha","family":"Kalotra","sequence":"first","affiliation":[{"name":"Department of Biotechnology Guru Nanak Dev University Amritsar Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vedangana","family":"Saini","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Guru Nanak Dev University Amritsar Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harpal","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Guru Nanak Dev University Amritsar Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuradha","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Guru Nanak Dev University Amritsar Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurcharan","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Guru Nanak Dev University Amritsar Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2217\/rme.10.72"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1088\/1748-6041\/7\/1\/012001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2009.1177"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2285"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2006.08.003"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.05.009"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp128"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12408"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13383"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep26927"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.06.038"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36011"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36675"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/jbm.a.32359","article-title":"The effect of laminin peptide gradient in enzymatically cross\u2010linked collagen scaffolds on neurite growth","volume":"92","author":"Yao L.","year":"2010","journal-title":"J. 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