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Progression of GERD may occur in asymptomatic patients and in those under continuous acid\u2010suppressive medication. The long\u2010term side effects of proton\u2010pump inhibitors, chemopreventive agents, and radiofrequency ablation are contentious. In patients with early\u2010stage disease, when the lower esophageal sphincter function is still preserved and before endoscopically visible Barrett's esophagus develops, novel laparoscopic procedures, such as magnetic and electric sphincter augmentation, may have a greater role than conventional surgical therapy. A multidisciplinary approach to GERD by a dedicated team of gastroenterologists and surgeons might impact the patients\u2019 lifestyle, the therapeutic choices, and the course of the disease. Biological markers are needed to precisely assess the risk of disease progression and to tailor surveillance, ablation, and management.<\/jats:p>","DOI":"10.1111\/nyas.14350","type":"journal-article","created":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T09:26:59Z","timestamp":1586338019000},"page":"117-126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Clinical course of gastroesophageal reflux disease and impact of treatment in symptomatic young patients"],"prefix":"10.1111","volume":"1481","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4880-1670","authenticated-orcid":false,"given":"Luigi","family":"Bonavina","sequence":"first","affiliation":[{"name":"Division of General and Foregut Surgery, Department of Biomedical Sciences for Health, University of Milan IRCCS Policlinico San Donato  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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