{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:49:34Z","timestamp":1793213374795,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T00:00:00Z","timestamp":1588723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Vicerrectorado de Investigaci\u00f3n - Universidad Nacional del Altiplano"}],"content-domain":{"domain":["nyaspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anemia diagnosis in populations residing at high altitude (HA) involves an adjustment of hemoglobin (Hb) values owing to the increase in its concentration with altitude. The suitability of the adjustment has been questioned since Hb concentrations depend on how adapted a population is to HA. In Peru, anemia in preschool children (PSC) is a matter of severe public concern for its high rates; in the city of Puno (\u223c3800 MASL), for example, 67.7% of children under 3 years are diagnosed with anemia. Here, we conducted an observational study in PSC living at different altitudes in Puno to assess Hb, iron status, and the suitability of altitude\u2010adjusted Hb values in defining iron deficiency anemia. After adjusting Hb, 65.66% of the population had anemia, while only 4.8% of PSC had anemia when using unadjusted Hb. Receiver\u2010operating characteristic curves using total body iron (TBI) as a marker of iron status are presented. In the 36\u2010 to 59\u2010month age group, unadjusted Hb performed better than altitude\u2010adjusted Hb. In the 6\u2010 to 35\u2010month age group, anemia (adjusted or unadjusted) was not associated with TBI. We conclude that Hb adjustment by altitude is not appropriate. Anemia at an early age is not entirely attributable to iron deficiency.<\/jats:p>","DOI":"10.1111\/nyas.14356","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T15:15:58Z","timestamp":1588778158000},"page":"35-47","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Is the prevalence of anemia in children living at high altitudes real? An observational study in Peru"],"prefix":"10.1111","volume":"1473","author":[{"given":"Benita Maritza","family":"Choque\u2010Quispe","sequence":"first","affiliation":[{"name":"Facultad de Ciencias de la Salud Universidad Nacional del Altiplano Puno Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0300-4683","authenticated-orcid":false,"given":"Dulce E.","family":"Alarc\u00f3n\u2010Yaquetto","sequence":"additional","affiliation":[{"name":"Laboratorio de Endocrinolog\u00eda y Reproducci\u00f3n, Facultad de Ciencias y Filosof\u00eda Universidad Peruana Cayetano Heredia Lima Peru"},{"name":"Instituto de Investigaciones en Altura Universidad Peruana Cayetano Heredia Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilber","family":"Paredes\u2010Ugarte","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud Universidad Nacional del Altiplano Puno Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Zaira","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud Universidad Nacional del Altiplano Puno Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelayda","family":"Ochoa","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud Universidad Nacional del Altiplano Puno Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo F.","family":"Gonzales","sequence":"additional","affiliation":[{"name":"Laboratorio de Endocrinolog\u00eda y Reproducci\u00f3n, Facultad de Ciencias y Filosof\u00eda Universidad Peruana Cayetano Heredia Lima Peru"},{"name":"Instituto de Investigaciones en Altura Universidad Peruana Cayetano Heredia Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2015.11.002"},{"key":"e_1_2_8_3_1","unstructured":"WHO.1959.Iron deficiency anaemia. 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