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In order to develop a better understanding of the pathophysiology of and improve the diagnosis of esophageal disorders, such as gastroesophageal reflux disease (GERD) and achalasia, several new diagnostic tests, including intraluminal impedance, esophageal mucosal impedance, and the functional luminal imaging probe, have been developed. These technologies have proven valuable for assessment of the esophagus in recent years. They provide information on esophageal flow properties, mucosal integrity, lumen shape, and distensibility in esophageal disorders, in particular for GERD and achalasia. Despite their promise and novel clinical studies, the potential of these technologies has been far from realized. New multidisciplinary approaches will contribute to our understanding and interpretation of esophageal impedance data and disease mechanisms.<\/jats:p>","DOI":"10.1111\/nyas.14408","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T21:09:22Z","timestamp":1592428162000},"page":"139-153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Impedance in the evaluation of the esophagus"],"prefix":"10.1111","volume":"1481","author":[{"given":"Peter I.","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, St George Hospital University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua A.","family":"Sloan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiko","family":"Kuribayashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Gunma University Hospital  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Gregersen","sequence":"additional","affiliation":[{"name":"GIOME, Department of Surgery The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,17]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"465","volume-title":"Urodynamics","author":"Harris J.H.","year":"2014"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.70.5.812"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(78)90699-6"},{"key":"e_1_2_9_5_1","first-page":"139","volume-title":"Chirurgiches forum 1989 f. experim. u. kliniche forschung","author":"Fass J.","year":"1989"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.1991.tb00061.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00257719"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)49471-7"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02443964"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1088\/0143-0815\/9\/4A\/011"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02446307"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-124-11-199606010-00002"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00496.2001"},{"key":"e_1_2_9_14_1","first-page":"640","article-title":"Central sensitization in patients with non\u2010cardiac chest pain: a clinical experimental pain study","volume":"41","author":"Drewes A.M.","year":"2006","journal-title":"World. 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