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Measurement of esophageal mucosal impedance, via either multichannel intraluminal impedance catheters or specially designed endoscopically deployed impedance catheters, provides a marker of mucosal integrity. Mucosal impedance has been shown to segregate gastroesophageal reflux disease (GERD) and eosinophilic esophagitis from non\u2010GERD controls and may play a role in predicting response to reflux intervention. More data are needed with regard to other esophageal subgroups, outcome studies, and functional disease. Our paper reviews the history of impedance in esophageal disease, the means of assessing baseline and mucosal impedance, data with regard to the newly developed mucosal impedance probes, the clinical utility of mucosal impedance in specific clinical conditions, and limitations in our existing knowledge, along with suggestions for future studies.<\/jats:p>","DOI":"10.1111\/nyas.14414","type":"journal-article","created":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T07:09:48Z","timestamp":1593155388000},"page":"247-257","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Mucosal impedance for esophageal disease: evaluating the evidence"],"prefix":"10.1111","volume":"1481","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2625-1169","authenticated-orcid":false,"given":"John O.","family":"Clarke","sequence":"first","affiliation":[{"name":"Department of Medicine Stanford University  Redwood City California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin K.","family":"Ahuja","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1709-8230","authenticated-orcid":false,"given":"Walter W.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medicine Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3388-0660","authenticated-orcid":false,"given":"C. 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