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Some brain areas are more prone to damage than others, so patients with hypoxic\u2013anoxic ischemic brain injury present with several outcomes, including reduced level of consciousness or alertness, memory deficits, uncoordinated movements, and seizures. Some patients may have mild deficits, while others may have such severe injury that it can progress to brain death. High\u2010quality cardiopulmonary resuscitation is a proven technique to improve outcome after cardiac arrest, although morbidity and mortality remain high. Induced hypothermia, which involves artificially cooling the body immediately after cardiac arrest, may reduce injury to the brain and improve morbidity and mortality. Neuroprognostication after cardiac arrest is challenging and requires a multimodal approach involving clinical neurologic examinations, brain imaging, electrical studies to assess brain activity, and biomarkers to predict outcome.<\/jats:p>","DOI":"10.1111\/nyas.14423","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T01:09:36Z","timestamp":1593738576000},"page":"12-22","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The critically ill brain after cardiac arrest"],"prefix":"10.1111","volume":"1507","author":[{"given":"Chaitanya B.","family":"Medicherla","sequence":"first","affiliation":[{"name":"Department of Neurology New York University Langone Medical Center  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0756-7320","authenticated-orcid":false,"given":"Ariane","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Neurology New York University Langone Medical Center  New York New York"},{"name":"Department of Neurosurgery New York University Langone Medical Center  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,2]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"136","article-title":"Updates on management of anoxic brain injury after cardiac arrest","volume":"112","author":"Ramiro J.I.","year":"2015","journal-title":"Mo. 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