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PPIs are used to treat acid\u2010related disorders, including gastroesophageal reflux disease, peptic ulcer disease, <jats:italic>Helicobacter pylori<\/jats:italic> infection, and nonsteroidal anti\u2010inflammatory drug\/stress ulceration. For some of these diseases, long\u2010term treatment is necessary. With such prolonged use, concern and investigation into potential adverse effects has increased. In addition, data are available regarding potential anticancer effects of PPIs, especially regarding solid tumors. The aim of this review is to assess the literature on PPIs with regard to common concerns, such as drug\u2013drug interactions, the intestinal microbiome, dementia and central nervous system disease, and osteoporosis, as well as to highlight potential negative and positive impacts of the drug in cancer.<\/jats:p>","DOI":"10.1111\/nyas.14428","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T22:46:52Z","timestamp":1596754012000},"page":"43-58","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Potential proton pump inhibitor\u2013related adverse effects"],"prefix":"10.1111","volume":"1481","author":[{"given":"Issac E.","family":"Perry","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Augusta University\u2010Medical College of Georgia  Augusta 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