{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T09:28:58Z","timestamp":1774949338126,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T00:00:00Z","timestamp":1597104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["nyaspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A variety of inflammatory disorders involve the esophagus. This commentary discusses the pathology of some forms of esophagitis, with an emphasis on recent developments. The initial section focuses on some common forms of nonreflux esophagitis, including lymphocytic esophagitis and eosinophilic esophagitis. Recent studies suggest that lymphocytic esophagitis may be associated with esophageal motility disorders and gastroesophageal reflux disease. Immunophenotypic features of intraepithelial lymphocytes may be helpful in distinguishing these conditions. Updates on the criteria and the limitations of histologic approach to the diagnosis of eosinophilic esophagitis are presented and new diagnostic adjuncts are discussed. In the remaining section, novel entities, such as IgG4\u2010related esophagitis, are discussed. IgG4\u2010related esophagitis has been recognized as a cause of esophageal lymphoplasmacytic inflammation. Increased understanding of esophageal inflammation remains an important goal that likely will lead to new approaches in the therapy of inflammatory esophageal diseases.<\/jats:p>","DOI":"10.1111\/nyas.14450","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T04:57:07Z","timestamp":1597208227000},"page":"5-10","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Inflammatory conditions of the esophagus: an update"],"prefix":"10.1111","volume":"1481","author":[{"given":"Mikhail","family":"Lisovsky","sequence":"first","affiliation":[{"name":"Department of Pathology Dartmouth\u2010Hitchcock Medical Center and Geisel Medical School at Dartmouth  Lebanon New Hampshire"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1309\/7LABLGY08UEM3H26"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2016-203782"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1309\/D3PCF6D6YYMQRX9A"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301014"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000493"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21347"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000100"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000712"},{"key":"e_1_2_5_10_1","first-page":"194A","article-title":"Frequency and nature of increased intraepithelial lymphocytes in biopsies from patients with achalasia [abstract]","volume":"27","author":"Muller K.E.","year":"2014","journal-title":"Mod. Pathol."},{"key":"e_1_2_5_11_1","first-page":"190A","article-title":"Lymphocytic esophagitis (LE) with CD8 T\u2010cell predominance may be associated with gastroesophageal reflux disease (GERD) [abstract]","volume":"29","author":"Olson N.","year":"2016","journal-title":"Mod. Pathol."},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3182500de8"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001394"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.07.009"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.08.046"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.08.043"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.11.028"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2014.132"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.08.030"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.02.024"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.05.036"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13486"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12892"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2006.04.037"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.463"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2010.078402"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-010-1172-4"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.8095-16"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.08.043"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/dox091"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.72"}],"container-title":["Annals of the New York Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnyas.14450","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nyas.14450","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nyas.14450","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nyas.14450","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T13:44:51Z","timestamp":1693748691000},"score":1,"resource":{"primary":{"URL":"https:\/\/nyaspubs.onlinelibrary.wiley.com\/doi\/10.1111\/nyas.14450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,11]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/nyas.14450"],"URL":"https:\/\/doi.org\/10.1111\/nyas.14450","archive":["Portico"],"relation":{},"ISSN":["0077-8923","1749-6632"],"issn-type":[{"value":"0077-8923","type":"print"},{"value":"1749-6632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,11]]},"assertion":[{"value":"2020-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}