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Flexible upper endoscopy offers the promise of filling in these gaps in a potentially minimally invasive approach. In this concise review, we focus on the plethora of endoluminal therapies available for the treatment of GERD. Therapies discussed include injectable agents, electrical stimulation of the lower esophageal sphincter, antireflux mucosectomy, radiofrequency ablation, and endoscopic suturing devices designed to create a fundoplication. As new endoscopic treatments become available, we come closer to the promise of the incisionless treatment of GERD. The known data surrounding the indications, benefits, and risks of these historical, current, and emerging approaches are reviewed in detail.<\/jats:p>","DOI":"10.1111\/nyas.14511","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T02:56:06Z","timestamp":1602816966000},"page":"121-129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Endoscopic treatments for GERD"],"prefix":"10.1111","volume":"1482","author":[{"given":"Bradley S.","family":"Kushner","sequence":"first","affiliation":[{"name":"Department of Surgery Washington University School of Medicine, Washington University in St. Louis  St. Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael M.","family":"Awad","sequence":"additional","affiliation":[{"name":"Department of Surgery Washington University School of Medicine, Washington University in St. Louis  St. Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean J.","family":"Mikami","sequence":"additional","affiliation":[{"name":"Department of Surgery, John A. 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