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We report about (1) cell\u2010free DNA (cfDNA), which reflects apoptosis; (2) corticotropin\u2010releasing hormone (CRH); (3) interleukin (IL)\u201015, which reflects inflammation; (4) granulocyte colony\u2013stimulating factor (G\u2010CSF); (5) vascular endothelial growth factor (VEGF); and (6) insulin\u2010like growth factor I (IGF\u2010I), which reflects follicular growth. Forty\u2010four poor responders and 44 normal responders\u2014according to the Bologna criteria\u2014were recruited. FF samples were prepared for cfDNA quantification employing Q\u2010PCR and for CRH, IL\u201015, G\u2010CSF, VEGF, and IGF\u2010I quantification employing ELISA. Statistically nonsignificant different levels of FF cfDNA, CRH, IL\u201015, VEGF, and IGF\u2010I were observed. Interestingly, statistically significant higher G\u2010CSF levels were observed in normal responders (302.48 \u00b1 474.36 versus 200.10 \u00b1 426.79 pg\/mL, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003). Lower cfDNA integrity was observed in cycles resulting in clinical pregnancy for both groups (normal: 0.07 \u00b1 0.04 versus 0.25 \u00b1 0.17 ng\/\u03bcL, <jats:italic>P<\/jats:italic> &lt; 0.001; poor: 0.10 \u00b1 0.06 versus 0.26 \u00b1 0.12 ng\/\u03bcL, <jats:italic>P<\/jats:italic> &lt; 0.001). The results predominantly showcase similarities between normal and poor responders pertaining to inflammatory, apoptotic, and growth factors. This may be attributed to the employment of natural cycles in order to exclude controlled ovarian stimulation as a factor\u2014indicating its detrimental effect. As G\u2010CSF levels presented significantly higher in normal responders, its vital role in understanding a compromised ovarian response is highlighted.<\/jats:p>","DOI":"10.1111\/nyas.14517","type":"journal-article","created":{"date-parts":[[2020,11,14]],"date-time":"2020-11-14T13:42:11Z","timestamp":1605361331000},"page":"78-90","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Investigating apoptotic, inflammatory, and growth markers in poor responders undergoing natural <i>in vitro<\/i> fertilization cycles: a pilot study"],"prefix":"10.1111","volume":"1489","author":[{"given":"Konstantinos","family":"Sfakianoudis","sequence":"first","affiliation":[{"name":"Genesis Athens Clinic Center for Human Reproduction  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petroula","family":"Tsioulou","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical School National 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