{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:00:42Z","timestamp":1793138442513,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T00:00:00Z","timestamp":1603670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["nyaspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of the New York Academy of Sciences"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Whether T cells promote bone loss following immobilization after spinal cord injury (SCI) remains undetermined. Therefore, wild\u2010type (WT) and T cell\u2013deficient (<jats:italic>Tcrb<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>) male mice underwent sham or contusion SCI to cause hindlimb paralysis. Femurs were isolated and distal and midshaft regions were evaluated by microcomputed tomography scanning. Bone marrow (BM) levels of bone turnover markers, as well as receptor activator of nuclear factor\u2010kappa B ligand (RANKL) and osteoprotegerin (OPG), were measured by ELISA. At 2 weeks post\u2010SCI, immobilization resulted in marked reduction in trabecular fractional bone volume (55%), thickness (40%), connectivity, and cortical thickness only in the <jats:italic>Tcrb<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> animals (interaction with <jats:italic>P<\/jats:italic> &lt; 0.05). BM analysis revealed lower bone formation (procollagen type 1 intact N\u2010terminal propeptide), higher bone resorption (tartrate\u2010resistant acid phosphatase\u20105b), and a higher RANKL\/OPG ratio in the <jats:italic>Tcrb<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> SCI animals. At 5 weeks post\u2010SCI, while both WT and <jats:italic>Tcrb<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> paralyzed animals showed deterioration of all indices of bone structure, they were more severe in <jats:italic>Tcrb<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> animals. In summary, unlike other skeletal disorders, loss of \u03b1\u03b2 T cells compromises, rather than preserves, skeletal integrity under conditions of immobilization.<\/jats:p>","DOI":"10.1111\/nyas.14518","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T03:11:38Z","timestamp":1603768298000},"page":"43-55","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Absence of \u03b1\u03b2 T cells accelerates disuse bone loss in male mice after spinal cord injury"],"prefix":"10.1111","volume":"1487","author":[{"given":"Karim","family":"Sahbani","sequence":"first","affiliation":[{"name":"National Center for the Medical Consequences of Spinal Cord Injury, James J Peters Veterans Affairs Medical Center  Bronx New York"},{"name":"Bronx Veterans Medical Research Foundation Inc.  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